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CAS 5697-56-3

:

Carbenoxolone

Description:
Carbenoxolone is a synthetic compound derived from glycyrrhetinic acid, primarily known for its use in medicinal applications, particularly as an anti-inflammatory and ulcer-healing agent. It functions by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, which plays a crucial role in the metabolism of corticosteroids. This inhibition can lead to increased local concentrations of active glucocorticoids, enhancing its therapeutic effects. Carbenoxolone exhibits properties that may promote mucosal healing and reduce gastric acid secretion, making it beneficial in treating conditions like peptic ulcers and gastroesophageal reflux disease. The substance is typically administered in the form of its sodium salt, which enhances its solubility and bioavailability. While generally well-tolerated, potential side effects may include electrolyte imbalances and hypertension due to its mineralocorticoid-like effects. As with any pharmacological agent, its use should be monitored, particularly in patients with pre-existing conditions that may be exacerbated by corticosteroid activity. Overall, carbenoxolone represents a valuable therapeutic option in gastrointestinal medicine.
Formula:C34H52O8
InChI:InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23?,24-,27?,30+,31-,32-,33+,34+;;/m0../s1
InChI key:InChIKey=OBZHEBDUNPOCJG-WBXJDKIVSA-N
SMILES:C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](OC(CCC(O)=O)=O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]
Synonyms:
  • (3Beta)-3-[(3-Carboxypropanoyl)Oxy]-11-Oxoolean-12-En-30-Oic Acid
  • (3beta)-3-[(3-Carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid Carbenoxolone
  • (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
  • 3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid
  • 3-O-(β-Carboxypropionyl)-11-oxo-18β-olean-12-en-30-oic acid
  • 3β-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
  • 8Xi,10Xi,17Xi,18Xi)-3-[(3-Carboxypropanoyl)Oxy]-11-Oxoolean-12-En-30-Oic Acid
  • Biogastrone
  • Disodium (3Beta,5Xi,9Xi)-3-[(3-Carboxylatopropanoyl)Oxy]-11-Oxoolean-12-En-30-Oate
  • Glycyrrhetinic Acid Hydrogen Succinate
  • See more synonyms
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