CAS 56973-12-7

8-methyladenosine

Description:

8-Methyladenosine, with the CAS number 56973-12-7, is a modified nucleoside derived from adenosine, characterized by the addition of a methyl group at the nitrogen atom in the 8-position of the purine ring. This modification is significant in various biological processes, particularly in the regulation of RNA metabolism and function. 8-Methyladenosine is known to play a role in the stability and translation of messenger RNA (mRNA), influencing gene expression and cellular responses. It is often found in eukaryotic cells and is implicated in the modulation of RNA splicing, transport, and degradation. The presence of this methylation can affect the interaction of RNA with proteins and other molecules, thereby impacting cellular processes. In terms of physical properties, 8-methyladenosine is typically a white to off-white solid, soluble in water and polar solvents, and it exhibits characteristic UV absorbance due to its nucleobase structure. Its study is crucial in understanding epitranscriptomics, the field that explores RNA modifications and their functional implications in cellular biology.

Formula: C₁₁H₁₅N₅O₄

InChI: InChI=1/C11H15N5O4/c1-4-15-6-9(12)13-3-14-10(6)16(4)11-8(19)7(18)5(2-17)20-11/h3,5,7-8,11,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

SMILES: Cc1nc2c(N)ncnc2n1[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)O

Synonyms:

• Adenosine, 8-Methyl-
• 8-Methyladenosine

8-Methyladenosine

CAS: 56973-12-7

Ref: 7W-GN9125

8-Methyladenosine

CAS: 56973-12-7

Nucleoside Derivatives - 8-Modified purine nucleosides; Naturally modified ribo-nucleosides

Formula: C₁₁H₁₅N₅O₄

Color and Shape: Solid

Molecular weight: 281.27

Ref: TM-TNU0288

8-Methyladenosine

CAS: 56973-12-7

8-Methyladenosine is an acid conjugate that can be found in the urine of healthy people. It is a protonated molecule that binds to a p2 subtype of the G protein-coupled receptor, which is activated by adenosine and 8-methyladenosine. This drug has been used in clinical trials for the treatment of herpes simplex virus and cervical cancer. The intramolecular hydrogen bond between the methyl group and the adenosine ring is responsible for its high binding affinity for this receptor. The glycosidic bond is formed when an 8-methyladenosine molecule attaches to a receptor on a cell surface, forming an intramolecular hydrogen bond with the receptor's amino acid side chain. This bond is broken when a protonated molecule of 8-methyladenosine enters the cell and interacts with the receptor, resulting in activation of this receptor.

Formula: C₁₁H₁₅N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 281.27 g/mol

Ref: 3D-NM08548