CAS 56974-61-9

Gabexate mesilate

Description:

Gabexate mesilate is a synthetic compound primarily known for its role as a protease inhibitor. It is often utilized in clinical settings to manage conditions related to excessive proteolytic activity, such as pancreatitis and certain surgical procedures. The substance is characterized by its ability to inhibit serine proteases, which are enzymes that play crucial roles in various physiological processes, including inflammation and coagulation. Gabexate mesilate is typically administered intravenously and is known for its relatively rapid onset of action. In terms of its chemical structure, it features a mesilate group, which enhances its solubility and bioavailability. The compound is generally well-tolerated, although potential side effects may include gastrointestinal disturbances and allergic reactions. Its pharmacological profile makes it a valuable therapeutic agent in managing acute and chronic conditions where protease activity is a concern. Overall, Gabexate mesilate exemplifies the application of synthetic compounds in modern medicine, particularly in the context of enzyme modulation.

Formula: C₁₆H₂₃N₃O₄·CH₄O₃S

InChI: InChI=1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

InChI key: InChIKey=DNTNDFLIKUKKOC-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C1=CC=C(OC(CCCCCNC(=N)N)=O)C=C1.S(C)(=O)(=O)O

Synonyms:

• 39492-01-8
• 4-[[6-[(Aminoiminomethyl)Amino]-1-Oxohexyl]Oxyl]Benzoic Acid Ethyl Ester Mesylate Salt
• Arodate
• Arodate (TN)
• Benzoic acid, 4-((6-((aminoiminomethyl)amino)-1-oxohexyl)oxy)-, ethyl ester, monomethanesulfonate
• Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester, methanesulfonate (1:1)
• Ethyl p-(6-guanidinohexanoxyloxy)benzoate methanesulfonate
• Ethyl p-(6-guanidinohexanoyloxy) benzoate methanesulfonate
• Ethyl p-hydroxybenzoate 6-guanidinohexanoate
• FOY
• Foy 007
• Foy-S 983
• Gabexate mesilate
• Gabexate mesilate (JP14)
• Gabexate monomethanesulfonate
• Gabexato [INN-Spanish]
• Gabexato mesilato [Spanish]
• Gabexatum [INN-Latin]
• Megacart
• Megacert
• Mesyl gabexate
• Methanesulfonate
• Reminaron
• [N-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium
• p-Hydroxybenzoic acid ethyl ester 6-guanidinohexanoate mesilate

Gabexate Mesylate

CAS: 39492-01-8, 56974-61-9

Formula: C₁₆H₂₃N₃O₄·CH₄O₃S

Purity: >97.0%(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 417.48

Ref: 3B-G0464

Benzoic acid, 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethylester, monomethanesulfonate

CAS: 56974-61-9

Formula: C₁₇H₂₇N₃O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 417.4772

Ref: IN-DA00IA62

Gabexate mesylate

CAS: 56974-61-9

Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.

Formula: C₁₇H₂₇N₃O₇S

Purity: 99.2% - 99.64%

Color and Shape: White Crystal

Molecular weight: 417.48

Ref: TM-T0372

Gabexate mesylate

CAS: 56974-61-9

Gabexate mesylate

Formula: C₁₆H₂₃N₃O₄·CH₃SO₃H

Purity: 99%

Color and Shape: white solid

Molecular weight: 417.48g/mol

Ref: 54-OR913282

Gabexate mesylate

CAS: 56974-61-9

Gabexate mesylate

Purity: ≥98%

Molecular weight: 417.48g/mol

Ref: 54-BUP13594

Gabexate mesylate

CAS: 56974-61-9

Formula: C₁₆H₂₃N₃O₄·CH₄O₃S

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 417.48

Ref: 7W-GP8018

Gabexate Mesilate RS

CAS: 56974-61-9

Color and Shape: White

Ref: 2K-1036000021

Gabexate mesylate

Controlled Product

CAS: 56974-61-9

Applications Gabexate mesylate is used in combination with somatostatin and octreotide in the treatment of severe acute pancreatitis in elderly patients.
References Li, X., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 3719 (2014); Wei, Q., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 5346 (2014)

Formula: C₁₆H₂₃N₃O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 417.48

Ref: TR-G122803

Gabexate mesylate

CAS: 56974-61-9

Serine protease inhibitor

Formula: C₁₇H₂₇N₃O₇S

Purity: Min. 95%

Molecular weight: 417.15697

Ref: 3D-FG23639

Ethyl 4-((6-guanidinohexanoyl)oxy)benzoate methanesulfonate

CAS: 56974-61-9

Purity: 98%

Molecular weight: 417.480011

Ref: 10-F868866

Gabexate Mesylate

Controlled Product

CAS: 56974-61-9

Applications Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Neuroresearch & Neuroprotective Product.
References Yuksel, M. et al.: J. Pharmacol. Exp. Therap., 305, 298 (2003); Tamura, Y. et al.: Biochim. Biophys. Acta, 484, 417 (1977); Ohno, H. et al.: Thromb. Res., 24, 445 (1981);

Formula: C₁₆H₂₃N₃O₄·CH₄O₃S

Color and Shape: Neat

Molecular weight: 417.48

Ref: TR-G122800