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CAS 56980-93-9

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Celiprolol

Description:
Celiprolol is a selective beta-1 adrenergic receptor blocker with additional properties as a partial agonist at beta-2 receptors. It is primarily used in the treatment of hypertension and certain types of heart conditions. The compound exhibits a unique dual action, providing both antihypertensive effects and a mild vasodilatory effect due to its beta-2 agonism, which can help improve blood flow. Celiprolol is characterized by its relatively long half-life, allowing for once-daily dosing, which enhances patient compliance. It is generally well-tolerated, with a side effect profile that may include fatigue, dizziness, and gastrointestinal disturbances. Importantly, it is less likely to cause bronchoconstriction compared to non-selective beta-blockers, making it a safer option for patients with respiratory conditions. Celiprolol's chemical structure includes a phenyl ring and a hydroxyl group, contributing to its pharmacological properties. As with any medication, it is essential to consider contraindications and interactions with other drugs when prescribing celiprolol.
Formula:C20H33N3O4
InChI:InChI=1/C20H33N3O4/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26)
InChI key:InChIKey=JOATXPAWOHTVSZ-UHFFFAOYSA-N
SMILES:O(CC(CNC(C)(C)C)O)C1=C(C(C)=O)C=C(NC(N(CC)CC)=O)C=C1
Synonyms:
  • (R,S)-Celiprolol
  • 1-[3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3,3-diethylurea
  • 3-[3-Acetyl-4-(2-Hydroxy-3-Tert-Butylamino-Propoxy)-Phenyl]-1,1-Diethyl-Urea
  • 3-{3-Acetyl-4-[3-(Tert-Butylamino)-2-Hydroxypropoxy]Phenyl}-1,1-Diethylurea
  • <span class="text-smallcaps">DL</span>-Celiprolol
  • N′-[3-Acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethylurea
  • Racemic Celiprolol
  • Selectol
  • Urea, N′-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-
  • dl-Celiprolol
  • See more synonyms
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