CAS 56985-40-1

U 46619

Description:

U 46619 is a synthetic compound that is primarily recognized as a potent thromboxane A2 (TXA2) receptor agonist. It is characterized by its ability to induce vasoconstriction and platelet aggregation, making it significant in studies related to cardiovascular physiology and pathology. The compound is often utilized in research to explore the role of thromboxane in various biological processes, including inflammation and hemostasis. U 46619 is typically administered in experimental settings to investigate its effects on vascular smooth muscle and its potential implications in conditions such as hypertension and atherosclerosis. Its chemical structure features a unique arrangement that contributes to its receptor binding affinity and biological activity. As a research tool, U 46619 aids in the understanding of TXA2's role in health and disease, although it is not used therapeutically in clinical settings. Safety and handling precautions are essential when working with this compound, as with any chemical substance, to mitigate potential hazards associated with its use.

Formula: C₂₁H₃₄O₄

InChI: InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18+,19-,20-/m1/s1

InChI key: InChIKey=LQANGKSBLPMBTJ-BRSNVKEHSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)[C@]2(C[C@@]1(CO2)[H])[H]

Synonyms:

• (15S)-Hydroxy-9α-11α-(methanoepoxy)prosta-5Z-13E dienoic acid
• (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid
• (5Z)-7-{(1S,4S,6S)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
• 11α,9α-Epoxymethanoprostaglandin H₂
• 2-Oxabicyclo[2.2.1]heptane, 5-heptenoic acid deriv.
• 5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-
• 5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-
• 5-Heptenoic acid, 7-[6-(3-hydroxy-1-octenyl)-2-oxabicyclo[2.2.1]hept-5-yl]-, [1R-[1α,4α,5β(Z),6α(1E,3S*)]]-
• 9,11-Dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F2alpha
• 9,11-Methanoepoxy PGH₂
• 9,11-dideoxy-11A,9A-epoxymethano-*prostaglandin F
• 9,11-dideoxy-9α,11α-methanoepoxyprostaglandin F_2α
• 9α,11α-Methanoepoxy-PGF_2α

U-46619

CAS: 56985-40-1

Formula: C₂₁H₃₄O₄

Purity: 98%

Molecular weight: 350.4923

Ref: IN-DA00E9NW

U-46619

CAS: 56985-40-1

U-46619

Purity: ≥95%

Molecular weight: 350.496g/mol

Ref: 54-OR1004344

U 46619

Controlled Product

CAS: 56985-40-1

Formula: C₂₁H₃₄O₄

Color and Shape: Neat

Molecular weight: 350.492

Ref: TR-U100210

U 46619

CAS: 56985-40-1

U 46619 is an analog of the peptide neurotransmitter acetylcholine. It is a potent and specific agonist for the nicotinic acetylcholine receptor (nAChR) in cardiac muscle cells. U 46619 binds to the cation channel on the nAChR, leading to changes in membrane potential and increased calcium influx. This drug has been shown to have positive effects on ventricular myocytes by increasing whole-cell voltage-clamp currents in rat cardiomyocytes. The biological properties of U 46619 have been investigated using an experimental model with maternal blood as a source of antibodies against acetylcholine, which was used to detect binding of radioactively labeled U 46619 to the receptors in the blood serum. Clinical studies have demonstrated that this drug may be useful for treating patients with heart failure or arrhythmias.

Formula: C₂₁H₃₄O₄

Purity: Min. 95%

Molecular weight: 350.5 g/mol

Ref: 3D-GCA98540

U-46619

CAS: 56985-40-1

U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (

Formula: C₂₁H₃₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 350.49

Ref: TM-T17189