CAS 57-22-7: (+)-Vincristine

Description: (+)-Vincristine is a complex alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily known for its potent antineoplastic properties, making it a critical agent in cancer chemotherapy, particularly for treating leukemia and certain types of lymphoma. The compound exhibits a unique structure characterized by a tetracyclic core and a vinorine moiety, contributing to its biological activity. (+)-Vincristine functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cell proliferation. It is typically administered intravenously and is known for its side effects, which can include neurotoxicity, constipation, and myelosuppression. The substance is classified as a prescription medication and is subject to strict regulatory controls due to its potent effects and potential toxicity. Its mechanism of action and therapeutic applications have made it a subject of extensive research in oncology, highlighting the importance of natural products in drug development.

Formula: C₄₆H₅₆N₄O₁₀

InChI: InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

InChI key: InChIKey=OGWKCGZFUXNPDA-CFWMRBGOSA-N

SMILES: O=CN1C2=CC(OC)=C(C=C2C34CCN5CC=CC(CC)(C(OC(=O)C)C(O)(C(=O)OC)C13)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CCN9CC(CC(O)(C9)CC)C6

Synonyms:

• (+)-Vincristine
• 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
• 22-Oxovincaleukoblastine
• 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
• Alcrist
• Biocristin
• Cyctocristine
• LCR
• Leucristine
• Leurocristine
• OncoTCS
• Oncocristin-AQ
• VCR
• Vincristin
• Vincristina
• Vincryst
• Vinkristin
• Vinlon
• Vinstin
• HSDB 3199
• Vincrystine
• NSC 67574
• Vincristinum
• Vincristine [INN:BAN]
• UNII-5J49Q6B70F
• Vincristinum [INN-Latin]
• Vincaleukoblastine, 22-oxo-
• Vincristina [DCIT]
• (2ξ,2'β,19ξ)-22-oxovincaleukoblastine
• NCI-C04864
• CCRIS 5763
• NSC-67574
• Vincaleukoblastine, 22-oxo-
• Onco TCS

Vincaleukoblastine, 22-oxo-

CAS: 57-22-7

• Formula: C₄₆H₅₆N₄O₁₀
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 824.9576

Vincristine

CAS: 57-22-7

• Purity: 99%
• Molecular weight: 824.96g/mol

Vincristine

CAS: 57-22-7

• Formula: C₄₆H₅₆N₄O₁₀
• Color and Shape: White To Off-White Solid
• Molecular weight: 824.97

Vincristine-d3

CAS: 57-22-7

• Formula: C₄₆H₅₃D₃N₄O₁₀
• Molecular weight: 827.99

Vincristine

CAS: 57-22-7

• Formula: C₄₆H₅₆N₄O₁₀
• Purity: 95%~99%
• Molecular weight: 824.972

Vincristine

CAS: 57-22-7

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• Formula: C₄₆H₅₆N₄O₁₀
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 824.96 g/mol

Vincristine

CAS: 57-22-7

Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.

• Formula: C₄₆H₅₆N₄O₁₀
• Purity: 100% - 98.46%
• Color and Shape: Solid
• Molecular weight: 824.96