CAS 57-22-7
:(+)-Vincristine
Description:
(+)-Vincristine is a complex alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily known for its potent antineoplastic properties, making it a critical agent in cancer chemotherapy, particularly for treating leukemia and certain types of lymphoma. The compound exhibits a unique structure characterized by a tetracyclic core and a vinorine moiety, contributing to its biological activity. (+)-Vincristine functions by inhibiting microtubule formation during cell division, effectively disrupting the mitotic spindle and preventing cancer cell proliferation. It is typically administered intravenously and is known for its side effects, which can include neurotoxicity, constipation, and myelosuppression. The substance is classified as a prescription medication and is subject to strict regulatory controls due to its potent effects and potential toxicity. Its mechanism of action and therapeutic applications have made it a subject of extensive research in oncology, highlighting the importance of natural products in drug development.
Formula:C46H56N4O10
InChI:InChI=1/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37?,38?,39-,42+,43-,44?,45+,46+/m1/s1
InChI key:InChIKey=OGWKCGZFUXNPDA-CFWMRBGOSA-N
SMILES:C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C=O)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)CC[N@@]9C[C@](C6)(C[C@](CC)(O)C9)[H])[H])CCN3CC=C2)[H]
Synonyms:- (+)-Vincristine
- 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv.
- 22-Oxovincaleukoblastine
- 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv.
- Alcrist
- Biocristin
- Cyctocristine
- LCR
- Leucristine
- Leurocristine
- OncoTCS
- Oncocristin-AQ
- VCR
- Vincristin
- Vincristina
- Vincryst
- Vinkristin
- Vinlon
- Vinstin
- HSDB 3199
- Vincrystine
- NSC 67574
- Vincristinum
- Vincristine [INN:BAN]
- UNII-5J49Q6B70F
- Vincristinum [INN-Latin]
- Vincaleukoblastine, 22-oxo-
- Vincristina [DCIT]
- (2ξ,2'β,19ξ)-22-oxovincaleukoblastine
- NCI-C04864
- CCRIS 5763
- NSC-67574
- Vincaleukoblastine, 22-oxo-
- Onco TCS
- Leucid
- Vincristine (base and/or unspecified salts)
- Vincosid
- Vincaleukoblastine, 22-oxo- (9CI)
- Pericristine
- Cristovin
- Vincristine ,VCR, NSC-67574, Oncovin
- methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(1R,13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0,12.0,1]nonadeca-4(12),5(10),6,8-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.0
- (2'β)-22-Oxovincaleukoblastine
- See more synonyms
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Found 6 products.
Vincaleukoblastine, 22-oxo-
CAS:Formula:C46H56N4O10Purity:98%Color and Shape:SolidMolecular weight:824.9576Vincristine
CAS:Controlled Product<p>Vincristine is a cytotoxic drug that inhibits the growth of tumor cells by interfering with DNA synthesis. It is used to treat various types of cancer, including lymphomas and leukemias. Vincristine has been shown to be effective in treating some infectious diseases, such as malaria and toxoplasmosis. It works by inhibiting the production of methyltransferase, an enzyme that is required for the synthesis of methionine. The long-term toxicity of vincristine has been studied extensively in mice, where it was found to cause congestive heart failure, but not lung tumors. Vincristine also appears to work synergistically with adriamycin in the treatment of squamous carcinoma.</p>Formula:C46H56N4O10Purity:Min. 95%Color and Shape:PowderMolecular weight:824.96 g/molVincristine
CAS:Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.Formula:C46H56N4O10Purity:98.46% - >99.99%Color and Shape:SolidMolecular weight:824.96
