CAS 57-47-6

(-)-Physostigmine

Description:

(-)-Physostigmine, also known as eserine, is a reversible inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the breakdown of the neurotransmitter acetylcholine. This compound is derived from the Calabar bean and is characterized by its ability to enhance cholinergic transmission, making it significant in the treatment of conditions such as glaucoma and myasthenia gravis. Chemically, it is classified as a carbamate and features a complex structure that includes a phenolic group and a tertiary amine. Its molecular formula is C15H16N2O2, and it exhibits a chiral center, with the (-)-enantiomer being the biologically active form. Physostigmine is soluble in water and organic solvents, and it has a relatively short half-life in the body, necessitating careful dosing. Due to its potent effects on the nervous system, it can also lead to side effects such as bradycardia and increased salivation if not administered properly. Overall, (-)-Physostigmine is a valuable pharmacological agent with significant implications in neuropharmacology.

Formula: C₁₅H₂₁N₃O₂

InChI: InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1

InChI key: InChIKey=PIJVFDBKTWXHHD-HIFRSBDPSA-N

SMILES: C[C@]12C=3C(N(C)[C@]1(N(C)CC2)[H])=CC=C(OC(NC)=O)C3

Synonyms:

• (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate
• 1,3A,8-Trimethyl-1,2,3,3A,8,8A-Hexahydropyrrolo[2,3-B]Indol-5-Yl Methylcarbamate
• Cogmine
• Esromiotin
• Fisostigmina
• Mcv 4484
• Nih 10421
• Nsc 30782
• Physostigmin
• Physostigmine
• Physostigmine 95%, 99%
• Physostol
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-

Physostigmine

CAS: 57-47-6

Formula: C₁₅H₂₁N₃O₂

Molecular weight: 275.35

Ref: 4Z-P-212

Eserine

CAS: 57-47-6

Formula: C₁₅H₂₁N₃O₂

Molecular weight: 275.35

Ref: 7W-GP4944

Physostigmine 100 µg/mL in Acetonitrile

CAS: 57-47-6

Formula: C₁₅H₂₁N₃O₂

Color and Shape: Single Solution

Molecular weight: 275.35

Ref: 04-A16192600AL-100

Physostigmine

Controlled Product

CAS: 57-47-6

Formula: C₁₅H₂₁N₃O₂

Color and Shape: Neat

Molecular weight: 275.35

Ref: 04-C16192600

Physostigmine

CAS: 57-47-6

Applications Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Engelhart, L., et al.: Arch. Exp. Pathol. Pharmakol., 150, 1 (1930), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 18, 289 (1989),

Formula: C₁₅H₂₁N₃O₂

Color and Shape: Neat

Molecular weight: 275.35

Ref: TR-P398500

Esromiotin

CAS: 57-47-6

Please enquire for more information about Esromiotin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₅H₂₁N₃O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 275.35 g/mol

Ref: 3D-FE59473

Physostigmine

CAS: 57-47-6

Physostigmine is a potent and reversible inhibitor of cholinesterase. It is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE).

Formula: C₁₅H₂₁N₃O₂

Purity: 98%

Color and Shape: Orthorhombic Sphenoidal Prisms Or Clusters Of Leaflets From Ether Or Benzene (Anticholinesterase) Agent And As A Veterinary Medication (Epa 1998)

Molecular weight: 275.35

Ref: TM-T21438