CAS 57-64-7

(-)-Physostigmine salicylate

Description:

(-)-Physostigmine salicylate, with the CAS number 57-64-7, is a reversible inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the breakdown of the neurotransmitter acetylcholine. This compound is derived from physostigmine, a natural alkaloid obtained from the Calabar bean, and is often used in the treatment of glaucoma and as an antidote for anticholinergic toxicity. It appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. The compound exhibits a chiral center, resulting in its specific optical activity, which is significant for its biological activity. Its mechanism of action involves the prolongation of acetylcholine's effects at synapses, enhancing cholinergic transmission. Due to its potent effects, (-)-Physostigmine salicylate must be used with caution, as it can lead to side effects such as bradycardia, muscle twitching, and increased salivation if overdosed. Proper dosage and monitoring are essential in clinical settings to ensure safety and efficacy.

Formula: C₁₅H₂₁N₃O₂·C₇H₆O₃

InChI: InChI=1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1

InChI key: InChIKey=HZOTZTANVBDFOF-PBCQUBLHSA-N

SMILES: C(O)(=O)C1=C(O)C=CC=C1.C[C@]12C=3C(N(C)[C@]1(N(C)CC2)[H])=CC=C(OC(NC)=O)C3

Synonyms:

• (3aS,8aR)-1,3a,8-trimethyl-5-[(methylcarbamoyl)oxy]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indolediium 2-oxidobenzoate
• 2-hydroxybenzoic acid - (3aS)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl N-methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Eserine salicylate salt
• Isopto Eserine
• Physostigmine salicylate
• Physostigmine, monosalicylate
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, mono(2-hydroxybenzoate) (salt)
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate) (salt)
• Salicylic acid, compd. with physostigmine (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
• ESERINE SALICYLATE 99.9%
• PHYSOSTIGMINE SALICYLATE SALT
• physostigmine,[salicylate(1:1)]
• ESERINE SALICYLATE
• physostigmine,salicylate(1:1)
• tl-1380
• ar-44
• ESERINE SALICYLATE(RG)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
• trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
• physostolsalicylate
• salicylicacid,compd.withphysostigmine(1:1)
• PHYSOSTIGMINESALICYLATE,USP
• ESERINE MONOSALICYLATE

PHYSOSTIGMINE SALICYLATE CRS

CAS: 57-64-7

PHYSOSTIGMINE SALICYLATE CRS

Formula: C₂₂H₂₇N₃O₅

Color and Shape: Colourless.

Molecular weight: 413.4669

Ref: 41-P1600000

Physostigmine Salicylate

CAS: 57-64-7

Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.

Formula: C₂₂H₂₇N₃O₅

Purity: 99.10% - >99.99%

Color and Shape: Crystal Form That Turns Red On Exposure To Heat Or Light (Epa 1998)

Molecular weight: 413.48

Ref: TM-T0130

Physostigmine Salicylate

CAS: 57-64-7

Formula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Molecular weight: 275.35 138.12

Ref: 4Z-P-214

Physostigmine Salicylate

CAS: 57-64-7

Color and Shape: Neat

Ref: 61-FOR1707.00

Physostigmine Salicylate

Controlled Product

CAS: 57-64-7

Formula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Color and Shape: Neat

Molecular weight: 413.47

Ref: 86-MM1707.00

Physostigmine Salicylate

Controlled Product

CAS: 57-64-7

Applications Physostigmine Salicylate is a cholinesterase inhibitor with the potential to improve cognitive ability in individuals with alzheimers. In addition, as a parasympathomimetic, it is used to treat glaucoma, dry mouth, and delayed gastric emptying. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Thal, L. et al.: Neurol., 47, 1389 (1996); Hedner, E. et al.: Eur. J. Oral Sci., 109, 374 (2001);

Formula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Color and Shape: Neat

Molecular weight: 413.47

Ref: TR-P398510

Physostigmine Salicylate

CAS: 57-64-7

Formula: C₁₅H₂₁N₃O₂C₇H₆O₃

Molecular weight: 275.35 : 138.12

Ref: ST-EA-CP-P350001

Physostigmine Salicylate

CAS: 57-64-7

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Formula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Color and Shape: White Powder Crystals

Molecular weight: 413.19507

Ref: 45-1537003