CAS 57-91-0

α-Estradiol

Description:

α-Estradiol, also known as 17β-estradiol, is a potent estrogen steroid hormone primarily involved in the regulation of the female reproductive system and secondary sexual characteristics. It is a colorless to pale yellow crystalline solid with a molecular formula of C18H24O2. This compound is characterized by its hydroxyl groups at the 17 and 3 positions, which are crucial for its biological activity. α-Estradiol is soluble in organic solvents such as ethanol and methanol but has limited solubility in water. It exhibits a melting point that typically falls within a specific range, indicating its stability under standard conditions. The substance plays a significant role in various physiological processes, including the menstrual cycle, pregnancy, and bone health. Additionally, α-Estradiol is utilized in hormone replacement therapy and contraceptive formulations. Its effects are mediated through estrogen receptors, influencing gene expression and cellular function. As a regulated substance, its use and handling require adherence to safety guidelines due to its biological activity and potential effects on human health.

Formula: C₁₈H₂₄O₂

InChI: InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1

InChI key: InChIKey=VOXZDWNPVJITMN-SFFUCWETSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC[C@H]2O)[H]

Synonyms:

• (17Alpha)-Estra-1,3,5(10)-Triene-3,17-Diol
• (17α)-Estra-1,3,5(10)-triene-3,17-diol
• (8Xi,13Xi,17Alpha)-Estra-1,3,5(10)-Triene-3,17-Diol
• 1,3,5-Estratriene-3,17-Alpha-Diol
• 1,3,5-Estratriene-3,17alpha-diol
• 1,3,5-Estratriene-3,17α-diol
• 13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol
• 17-Epiestradiol
• 17A-estradiol
• 17ALPHA-Estradiol
• 17alpha-Oestradiol
• 17α-Oestradiol
• 3,17-Alpha-Dihydroxyoestra-1,3,5(10)-Triene
• 3,17-Dihydroxyestratriene
• 3,17alpha-Dihydroxyestra-1,3,5(10)-triene
• 3,17alpha-Dihydroxyoestra-1,3,5(10)-triene
• 3,17α-Dihydroxyestra-1,3,5(10)-triene
• 3,17α-Dihydroxyoestra-1,3,5(10)-triene
• 5(10)-Triene-3,17-Diol,(17-Alpha)-Estra-3
• Alfatradiol
• Alpha-Estradiol
• Epiestradiol
• Epiestrol
• Estra-1,3,5(10)-Triene-3,17Α-Diol
• Estra-1,3,5(10)-Trieno-3,17Α-Diol
• Estra-1,3,5(10)-trien-3,17α-diol
• Estra-1,3,5(10)-triene-3,17-diol, (17alpha)-
• Estra-1,3,5(10)-triene-3,17-diol, (17α)-
• Estra-1,3,5(10)-triene-3,17alpha-diol
• Estradiol, 17alpha-
• Migenix
• Mito 4509
• Nsc 20293
• Oestra-1,3,5(10)-triene-3,17alpha-diol
• Oestra-1,3,5(10)-triene-3,17α-diol
• Oestradiol (E2), 17-Alpha-
• Oestradiol (E2), 17-Beta
• Oestradiol-17-Alpha
• Oestradiol-17alpha
• 3,17ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
• 17BETA-OESTRADIOL
• (8R,9S,13S,14S,17S)-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
• 1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL
• 17B-ESTRADIOL
• 1,3,5[10]-ESTRATRIENE-3,17ALPHA-DIOL
• 1,3,5(10)-ESTRATRIEN-2,17BETA-DIOL
• 1,3,5(10)-ESTRATRIEN-3,17-ALPHA-DIOL
• BETA-ESTRADIOL
• B-ESTRADIOL
• 17BETA-ESTRADIOL
• 1,3,5(10)-ESTRADRIEN-3,17A-DIOL
• 1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
• 3,17BETA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
• 1,3,5(10)-ESTRATRIEN-3,17-DIOL

17α-Estradiol (17-epi-Estradiol; Estra-1,3,5(10)-triene-3,17α-diol)

CAS: 57-91-0

Color and Shape: Neat

Ref: 61-FOR0300.01

1,3,5-Estratriene-3,17α-diol

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 272.3820

Ref: IN-DA003NS5

α-Estradiol

CAS: 57-91-0

α-Estradiol

Purity: 98%

Molecular weight: 272.39g/mol

Ref: 54-OR1025048

α-Estradiol

CAS: 57-91-0

α-Estradiol

Purity: ≥98%

Molecular weight: 272.38g/mol

Ref: 54-BUP16697

Estradiol EP Impurity B (Ethinylestradiol EP Impurity L, 17-epi-Estradiol)

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 272.39

Ref: 4Z-E-0935

Estradiol EP Impurity B-d3 (Ethinylestradiol EP Impurity L-d3, 17-epi-Estradiol-d3)

CAS: 57-91-0

Formula: C₁₈H₂₁D₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 275.41

Ref: 4Z-E-0938

17-α-Estradiol

Controlled Product

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Color and Shape: Neat

Molecular weight: 272.38

Ref: 04-C13213000

17α-Estradiol

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Purity: 95%~99%

Molecular weight: 272.388

Ref: BP-SBP03448

17-α-Estradiol 100 µg/mL in Acetonitrile

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Color and Shape: Single Solution

Molecular weight: 272.38

Ref: 04-XA13213000AL

α-Estradiol

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Purity: >98.0%(GC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 272.39

Ref: 3B-E0919

Estra-1,3,5(10)-triene-3,17α-diol (17α-Estradiol; 17-epi-Estradiol)

Controlled Product

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Color and Shape: Neat

Molecular weight: 272.38

Ref: 86-MM0300.01

α-Estradiol

CAS: 57-91-0

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Formula: C₁₈H₂₄O₂

Purity: 99.65% - 99.86%

Color and Shape: Solid

Molecular weight: 272.38

Ref: TM-T3378

17α-Estradiol

Controlled Product

CAS: 57-91-0

Impurity Estradiol 17?-Hydroxy Impurity; Estradiol EP Impurity B; Ethinylestradiol EP Impurity L
Applications Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain(1,2). 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke(3).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
References 1. Lievertz, R. et al.: J. Obstet. Gynecol. 1987 May;156(5):1289-932. Kuhnz, W. et al.: Arzneimittelforschung. 1993 Sep;43(9):966-73.3. Toran-Allerand, C. et al.: Endocrinology. 2005 Sep;146(9):3843-50.

Formula: C₁₈H₂₄O₂

Color and Shape: White

Molecular weight: 272.38

Ref: TR-E887995

17a-Estradiol

Controlled Product

CAS: 57-91-0

17a-Estradiol is a steroid hormone that belongs to the group of estrogens. It is a natural hormone produced by the ovaries and also found in plants, animals, and humans. 17a-Estradiol has been shown to have physiological effects on blood pressure, pro-apoptotic protein expression, allergic symptoms, and intracellular Ca2+ levels. 17a-Estradiol can be used to treat estrogen deficiency or as an adjunct treatment for breast cancer.

Formula: C₁₈H₂₄O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 272.38 g/mol

Ref: 3D-FE22820

(8R,9S,13S,14S,17R)-13-METHYL-6,7,8,9,11,12,14,15,16,17-DECAHYDROCYCLOPENTA[A]PHENANTHRENE-3,17-DIOL

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 272.388

Ref: 10-F513619

Estradiol Hemihydrate EP Impurity B

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Molecular weight: 272.39

Ref: ST-EA-CP-E58002

Ethinylestradiol EP Impurity L

CAS: 57-91-0

Formula: C₁₈H₂₄O₂

Molecular weight: 272.4

Ref: ST-EA-CP-E21012