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CAS 570-36-5

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Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-11,17-dihydroxy-, (6α,11β)-

Description:
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-11,17-dihydroxy-, (6α,11β)-, commonly known as fluocinolone acetonide, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is characterized by its steroidal structure, which includes a fluorine atom at the 6-position and an acetoxy group at the 21-position, contributing to its potency and stability. This compound is typically used in dermatological formulations to treat various skin conditions, such as eczema and psoriasis, due to its ability to reduce inflammation and suppress immune responses. Fluocinolone acetonide exhibits a high affinity for glucocorticoid receptors, leading to its effectiveness in modulating gene expression related to inflammation. The compound is generally administered topically, and its pharmacokinetics can vary based on the formulation and application method. Safety profiles indicate potential side effects, including skin atrophy and systemic absorption, particularly with prolonged use. Overall, fluocinolone acetonide is a valuable therapeutic agent in the management of inflammatory skin disorders.
Formula:C23H29FO6
InChI:InChI=1/C23H29FO6/c1-12(25)30-11-19(28)23(29)7-5-15-14-9-17(24)16-8-13(26)4-6-21(16,2)20(14)18(27)10-22(15,23)3/h4,6,8,14-15,17-18,20,27,29H,5,7,9-11H2,1-3H3/t14-,15-,17-,18-,20+,21-,22-,23-/m0/s1
InChI key:InChIKey=CYMBAKFTWRNHPS-APRQOCPKSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(COC(C)=O)=O)O)[H]
Synonyms:
  • (6Alpha,11Beta)-6-Fluoro-11,17-Dihydroxy-3,20-Dioxopregna-1,4-Dien-21-Yl Acetate
  • 21-Acetoxy-6α-fluoro-11β,17-dihydroxypregna-1,4-diene-3,20-dione
  • 6alpha-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • 6alpha-Fluoroprednisolone Acetate
  • 6α-Fluoroprednisolone-21-acetate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-11,17-dihydroxy-, (6α,11β)-
  • Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,17,21-trihydroxy-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6-fluoro-11,17-dihydroxy-, (6α,11β)- (9CI)
  • 6alpha-Fluprednisolone acetate
  • [2-[(6S,8S,9S,10R,11S,13S,14S,17R)-6-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • See more synonyms
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Found 1 products.
  • 6α-Fluoroprednisolone acetate
    Biosynth
    + Info

    6α-Fluoroprednisolone acetate

    Controlled Product
    CAS:
    6alpha-Fluoroprednisolone acetate is a corticosteroid that is used for the treatment of inflammatory diseases. It has a high therapeutic index and does not bind to mineralocorticoid receptors in the body. 6alpha-Fluoroprednisolone acetate is administered as an aerosol or a microsphere. It can be used in cell culture because it does not inhibit protein synthesis or cause morphological changes to cells. The drug has been shown to have a low cytotoxicity profile, which may be due to its ability to suppress pd-l1 and Mcl-1 proteins, which are associated with cancer metastasis. Clinical data suggests that 6alpha-fluoroprednisolone acetate has no adverse effects on the liver, kidney, or bone marrow.
    Formula:C23H29FO6
    Purity:Min. 95%
    Molecular weight:420.47 g/mol

    Ref: 3D-FF102549

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