CAS 57078-98-5

4-maleimidobutyric acid

Description:

4-Maleimidobutyric acid is a chemical compound characterized by its maleimide functional group, which is known for its reactivity towards thiols, making it valuable in bioconjugation and protein labeling applications. This compound typically appears as a white to off-white solid and is soluble in polar solvents such as water and dimethyl sulfoxide (DMSO). Its structure features a butyric acid moiety linked to a maleimide, providing both hydrophilic and reactive properties. The presence of the maleimide group allows for the formation of stable thioether bonds with sulfhydryl groups, facilitating the conjugation of biomolecules, such as proteins and peptides. 4-Maleimidobutyric acid is often utilized in the development of targeted drug delivery systems, biosensors, and in the study of protein interactions. Additionally, it is important to handle this compound with care, as it may pose health risks if ingested or inhaled, and appropriate safety measures should be taken during its use in laboratory settings.

Formula: C₈H₉NO₄

InChI: InChI=1/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13)

InChI key: InChIKey=NCPQROHLJFARLL-UHFFFAOYSA-N

SMILES: C(CCC(O)=O)N1C(=O)C=CC1=O

Synonyms:

• 1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-
• 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-butanoic acid
• 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid
• 4-Maleimidobutanoic acid
• N-(3-Carboxypropyl)maleimide
• γ-Maleimidobutyric acid
• ω-Maleimidobutyric acid
• 4-Maleimidobutyric acid
• MBA
• 4-MALEIMIDOBUTANOIC ACID DIHYDRATE
• RARECHEM AL CD 0913
• GAMMA-MALEIMIDOBUTYRIC ACID
• 4-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-BUTYRIC ACID
• N-MALEOYL-4-AMINOBUTYRIC ACID
• γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Carboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA
• N-MALEOYL-GABA

1H-Pyrrole-1-butanoic acid, 2,5-dihydro-2,5-dioxo-

CAS: 57078-98-5

Formula: C₈H₉NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 183.1614

Ref: IN-DA00IA6K

4-Maleimidobutyric acid

CAS: 57078-98-5

Formula: C₈H₉NO₄

Purity: ≥ 98.0%

Color and Shape: White to off-white crystalline powder or crystals

Molecular weight: 183.16

Ref: 7W-GK2333

4-Maleimidobutyric acid

CAS: 57078-98-5

4-Maleimidobutyric acid is an alkyl chain-derived PROTAC linker that enables the synthesis of PROTACs[1].

Formula: C₈H₉NO₄

Color and Shape: White Solid

Molecular weight: 183.16

Ref: TM-T14041

4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

CAS: 57078-98-5

4-(2,5-Dioxo-2H-pyrrol-1(5H)-yl)butanoic acid

Purity: 99%

Molecular weight: 183.16g/mol

Ref: 54-OR323076

4-Maleimidobutyric acid

CAS: 57078-98-5

4-Maleimidobutyric acid is a molecule that is used for the immobilization of peptides and proteins. It has been shown to bind to lysine residues on the surface of epidermal growth factor, which may be due to its ability to form covalent bonds with amino groups. This binding prevents the protein from interacting with cells in culture. 4-Maleimidobutyric acid also inhibits bacterial growth, including activity against Staphylococcus aureus, Bacillus anthracis, Mycobacterium tuberculosis, and Pseudomonas aeruginosa. 4-Maleimidobutyric acid has been shown to inhibit cancer cell proliferation in a Ca2+-dependent manner. It may also be effective as an antimicrobial agent due to its ability to disrupt proton gradients and acidic environments found in bacteria.

Formula: C₈H₉NO₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 183.16 g/mol

Ref: 3D-FM10662

4-Maleimidobutyric acid

CAS: 57078-98-5

Formula: C₈H₉NO₄

Purity: 95%

Color and Shape: Solid, White to very pale yellow powder

Molecular weight: 183.163

Ref: 10-F042434

4-Maleimidobutyric Acid

CAS: 57078-98-5

Formula: C₈H₉NO₄

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 183.16

Ref: 3B-M2337