CAS 571190-30-2
:Palbociclib
Description:
Palbociclib is an oral medication classified as a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), primarily used in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. Its chemical formula is C24H29N5O2, and it features a complex structure that includes a pyridazine ring, which is crucial for its biological activity. Palbociclib works by disrupting the cell cycle, specifically inhibiting the transition from the G1 phase to the S phase, thereby preventing cancer cell proliferation. The substance is typically administered in combination with aromatase inhibitors or estrogen receptor antagonists to enhance therapeutic efficacy. Palbociclib is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which can influence its bioavailability. Its pharmacokinetics indicate a significant first-pass metabolism, primarily by the liver, and it has a half-life that supports once-daily dosing. As with many targeted therapies, monitoring for side effects such as neutropenia is essential during treatment.
Formula:C24H29N7O2
InChI:InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChI key:InChIKey=AHJRHEGDXFFMBM-UHFFFAOYSA-N
SMILES:O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
Synonyms:- 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
- 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
- 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
- Ibrance
- Otava-Bb 1115529
- Palbociclib
- Palbociclib base
- Palbocyclib
- Pd 332991
- Pd 991
- Pd-0332991
- Pd0332991
- See more synonyms
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Found 16 products.
Palbociclib
CAS:Formula:C24H29N7O2Purity:>97.0%(T)(HPLC)Color and Shape:White to Yellow to Yellow green powder to crystalMolecular weight:447.54Palbociclib
CAS:Formula:C24H29N7O2Purity:(TLC) ≥ 98.0%Color and Shape:Yellow powderMolecular weight:447.53Palbociclib
CAS:<p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>Formula:C24H29N7O2Purity:98% - 99.9%Color and Shape:SolidMolecular weight:447.53Palbociclib Sulfate Sodium Salt
CAS:Controlled Product<p>Applications Palbociclib Sulfate is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C24H28N7NaO5SColor and Shape:NeatMolecular weight:549.58Palbociclib-d4
CAS:Controlled Product<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C24H25D4N7O2Color and Shape:Light YellowMolecular weight:451.56Palbociclib - Bio-X ™
CAS:<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C24H29N7O2Purity:Min. 95%Color and Shape:PowderMolecular weight:447.53 g/molPalbociclib
CAS:<p>Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.</p>Formula:C24H29N7O2Purity:Min. 95%Color and Shape:PowderMolecular weight:447.53 g/molPalbociclib-d4 Hydrochloride
CAS:Controlled Product<p>Applications Palbociclib-d4 Hydrochloride is an intermediate in synthesizing Palbociclib-d4 (P139901), an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C25H27D4N7O2·HClColor and Shape:NeatMolecular weight:465.58 + (36.46)Palbociclib N-β-D-Glucuronide Sodium Salt (Technical Grade, ~65%)
CAS:Controlled Product<p>Applications Palbociclib N-β-D-Glucuronide is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Formula:C30H36N7NaO8Purity:~65%Color and Shape:NeatMolecular weight:645.64Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Formula:C24H29N7O2Color and Shape:NeatMolecular weight:447.53Maillard Product
CAS:Controlled ProductFormula:C36H49N7O12Color and Shape:NeatMolecular weight:771.8146-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one
CAS:Formula:C24H29N7O2Color and Shape:SolidMolecular weight:447.5328
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