CAS 571203-78-6

Erastin

Description:

Erastin is a small molecule identified as a selective inducer of ferroptosis, a form of regulated cell death characterized by the accumulation of lipid peroxides. It is primarily studied for its potential therapeutic applications in cancer treatment, particularly in tumors that are resistant to conventional therapies. The compound functions by inhibiting the cystine/glutamate antiporter system Xc-, leading to decreased levels of intracellular cysteine and glutathione, which are crucial for cellular antioxidant defense. This results in increased oxidative stress and ultimately triggers ferroptotic cell death. Erastin has been shown to selectively target cancer cells while sparing normal cells, making it a promising candidate for further research in oncology. Additionally, its mechanism of action highlights the importance of metabolic pathways in cancer biology, providing insights into potential combination therapies that could enhance treatment efficacy. As research continues, understanding the full spectrum of Erastin's biological effects and its interactions with other cellular pathways will be essential for its development as a therapeutic agent.

Erastin

CAS: 571203-78-6

Formula: C₃₀H₃₁ClN₄O₄

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 547.05

Ref: 3B-E1524

Erastin

CAS: 571203-78-6

Formula: C₃₀H₃₁ClN₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 547.0445

Ref: IN-DA003PXQ

Erastin

CAS: 571203-78-6

Erastin

Formula: C₃₀H₃₁ClN₄O₄

Purity: 99%

Color and Shape: white solid

Molecular weight: 547.04g/mol

Ref: 54-BISN0097

Erastin

CAS: 571203-78-6

Formula: C₃₀H₃₁ClN₄O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 547.04

Ref: 7W-GL5645

Erastin

CAS: 571203-78-6

Erastin is an iron death activator that acts on the mitochondrial VDAC in a ROS- and iron-dependent manner, anti-tumor. High-Quality, Low-Cost!

Formula: C₃₀H₃₁ClN₄O₄

Purity: 98% - 99.75%

Color and Shape: Solid

Molecular weight: 547.04

Ref: TM-T1765

Erastin

Controlled Product

CAS: 571203-78-6

Applications Erastin is an eradicator of RAS and ST-expressing cells. An irreversible antitumor agent selectively killing cells expressing the small T oncoprotein and oncogenic Ras.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dolma, S. et al.: Cancer Cell., 3, 285 (2003); Yagoda, N. et al.: Nature, 447, 864 (2007);

Formula: C₃₀H₃₁ClN₄O₄

Color and Shape: Neat

Molecular weight: 547.04

Ref: TR-E593500

Erastin

CAS: 571203-78-6

Erastin is a polymerase chain inhibitor that specifically targets gene transcription. It has been shown to inhibit the activity of DNA-dependent RNA polymerase by binding to the alpha subunit and inhibiting its ability to use nucleotides as substrates for synthesis. Erastin also inhibits cell proliferation and induces apoptosis in leukemia cells. The synergistic effect of erastin with ferroptosis inhibitors has been shown to induce neuronal death in a model system, which may have therapeutic benefits in the treatment of neurodegenerative diseases such as Parkinson's disease.

Formula: C₃₀H₃₁ClN₄O₄

Purity: Min. 95%

Molecular weight: 547.04 g/mol

Ref: 3D-WXA20378