(+)-Primaquine is an antimalarial compound primarily used for the treatment and prevention of malaria, particularly in its vivax and ovale forms. It is classified as an 8-aminoquinoline and is known for its ability to target the liver stages of the malaria parasite, thus preventing relapse. The substance is characterized by its chiral nature, with the (+) designation indicating its specific optical activity. Chemically, it features a piperidine ring and a side chain that contributes to its pharmacological properties. (+)-Primaquine is typically administered in its phosphate form, which enhances its solubility and bioavailability. The compound exhibits a relatively low toxicity profile but can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Its mechanism of action involves the generation of reactive oxygen species, which disrupts the parasite's metabolic processes. Due to its unique properties, (+)-Primaquine plays a crucial role in malaria eradication efforts, especially in regions where relapsing malaria is prevalent.

(+)-Primaquine

57152-58-6: (+)-Primaquine is an antimalarial compound primarily used for the treatment and prevention of malaria, particularly in its vivax and ovale forms. It is classified as an 8-aminoquinoline and is known for its ability to target the liver stages of the malaria parasite, thus preventing relapse. The substance is characterized by its chiral nature, with the (+) designation indicating its specific optical activity. Chemically, it features a piperidine ring and a side chain that contributes to its pharmacological properties. (+)-Primaquine is typically administered in its phosphate form, which enhances its solubility and bioavailability. The compound exhibits a relatively low toxicity profile but can cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Its mechanism of action involves the generation of reactive oxygen species, which disrupts the parasite's metabolic processes. Due to its unique properties, (+)-Primaquine plays a crucial role in malaria eradication efforts, especially in regions where relapsing malaria is prevalent.

l-Primaquine is used to treat and prevent malaria and to treat Pneumocystis pneumonia.

CAS 57152-58-6

(+)-Primaquine

l-Primaquine

Ref: TM-T32891