CAS 57186-25-1

Paxilline

Description:

Paxilline is a naturally occurring alkaloid primarily derived from the fungus *Penicillium paxilli*. It is known for its complex structure, which includes a fused tetracyclic ring system. Paxilline exhibits significant biological activity, particularly as a potent inhibitor of certain ion channels, including voltage-gated potassium channels. This property makes it a valuable compound in pharmacological research, particularly in studies related to neurobiology and cardiovascular function. The substance is characterized by its relatively low solubility in water, which can affect its bioavailability and pharmacokinetics. Additionally, paxilline has been studied for its potential therapeutic applications, although its use is limited due to toxicity concerns. As with many alkaloids, it is important to handle paxilline with care, as it can exhibit toxic effects at higher concentrations. Overall, paxilline serves as an important tool in understanding ion channel dynamics and has implications for drug development in various therapeutic areas.

Formula: C₂₇H₃₃NO₄

InChI: InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1

InChI key: InChIKey=ACNHBCIZLNNLRS-UBGQALKQSA-N

SMILES: C[C@@]12[C@]3(C)[C@](O)(C=4[C@](CC3)(O[C@H](C(C)(C)O)C(=O)C4)[H])CC[C@]1(CC5=C2NC=6C5=CC=CC6)[H]

Synonyms:

• (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
• (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one
• 2H-1-Benzopyrano[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-
• 2H-1-Benzopyrano[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, [2R-(2α,4bβ,6aα,12bβ,12cα,14aβ)]-
• Paxicillin
• Paxiline
• Paxillin
• Paxilline

Paxilline, 97+%

CAS: 57186-25-1

Potent blocker of high-conductance calcium-activated potassium (BKCa) channels

Formula: C₂₇H₃₃NO₄

Purity: 97+%

Molecular weight: 435.56

Ref: 02-J61341

Paxilline

CAS: 57186-25-1

Formula: C₂₇H₃₃NO₄

Purity: 100.0%

Color and Shape: Yellowish. Powder

Molecular weight: 436.0

Ref: 8R-CL0035

Paxilline from Penicillium paxilli

CAS: 57186-25-1

Paxilline from Penicillium paxilli

Formula: C₂₇H₃₃NO₄

Purity: By hplc: 98.8% (280nm); 98.8% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 435.55522g/mol

Ref: 54-BIP1004

Paxilline

CAS: 57186-25-1

Paxilline, an indole alkaloid mycotoxin from Penicillium paxilli, is a specific inhibitor of BK-type K(+) channels with anticonvulsant activity.

Formula: C₂₇H₃₃NO₄

Purity: 98%

Color and Shape: White Powder

Molecular weight: 435.56

Ref: TM-T12373

Paxilline

CAS: 57186-25-1

Formula: C₂₇H₃₃NO₄

Purity: ≥ 97.5%

Color and Shape: White to off-white crystalline powder

Molecular weight: 435.56

Ref: 7W-GL8865

Paxilline, Penicillium paxilli

CAS: 57186-25-1

M02243 - Paxilline, Penicillium paxilli

Formula: C₂₇H₃₃NO₄

Purity: >98%

Color and Shape: Solid, Off-white powder

Molecular weight: 435.564

Ref: 10-M02243

Paxilline

Controlled Product

CAS: 57186-25-1

Applications Paxilline is a indole-diterpenes and a potent inhibitor of large conductance Ca2+-activated K+ currents in vascular smooth muscle cells
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tagami, K., et al.: J. Am. Chem. Soc. 35, 260 (2013); Li, G. and Cheung, W. Eur. J. Pharmacol 372, 103 (1999);

Formula: C₂₇H₃₃NO₄

Color and Shape: Neat

Molecular weight: 435.56

Ref: TR-P207600