CAS 57248-88-1

Pamidronate disodium

Description:

Pamidronate disodium is a bisphosphonate compound primarily used in the treatment of conditions characterized by excessive bone resorption, such as osteoporosis and Paget's disease, as well as in managing hypercalcemia associated with malignancies. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is typically administered intravenously due to its poor oral bioavailability. Pamidronate disodium is a white to off-white powder that is soluble in water, making it suitable for parenteral formulations. Its chemical structure features two phosphonate groups, which are responsible for its high affinity for bone tissue. The compound is generally well-tolerated, although it may cause side effects such as flu-like symptoms, gastrointestinal disturbances, and, in rare cases, osteonecrosis of the jaw. As with other bisphosphonates, it is essential to monitor renal function during treatment, as the drug is primarily excreted through the kidneys. Overall, pamidronate disodium plays a significant role in managing bone-related disorders.

Formula: C₃H₁₁NO₇P₂·2Na

InChI: InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;

InChI key: InChIKey=JFDLEPOYGUTJNG-UHFFFAOYSA-N

SMILES: C(P(=O)(O)O)(P(=O)(O)O)(CCN)O.[Na]

Synonyms:

• 3-Amino-1-Hydroxy-1-Phosphonopropyl Phosphonic Acid Disodium Salt
• 3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt
• APD (pharmaceutical)
• Aminomux
• Aredia
• Cgp 23339A
• Cgp 23339Ae
• Disodium (3-Amino-1-Hydroxypropane-1,1-Diyl)Bis[Hydrogen (Phosphonate)]
• Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate
• Disodium [3-amino-1-hydroxy-1-(hydroxy-oxidophosphoryl)propyl]-hydroxyphosphinate
• Pamidronate Disodium
• Pamidronate Disodium Salt
• Pamidronic acid disodium salt
• Pamimed
• Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt
• Phosphonic acid, P,P′-(3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
• phosphonate, P,P'-(3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
• APD
• PAMIDRONATE DISODIUM SALT HYDRATE
• (3-amino-1-hydroxypropylidene)diphosphonicaciddisodiumsalt
• cgp23339a
• (3-AMINO-1-HYDROXYPROPYLIDINE)BIS-PHOSPHONIC ACID
• disodium dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate
• aminohydroxypropylidenediphosphonatedisodiumsalt
• disodium3-amino-1-hydroxypropylidene-1,1-biphosphonatepentahydrate
• (3-Amino-1-hydroxypropylidene)bisphosphonic Acid Disodium
• 3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid hydrate disodium salt
• 3-AMINO-1-HYDROXYPROPYLIDENE-BISPHOSPHONIC ACID, 2NA, PENTAHYDRATE
• PAMIDRONICDISODIUMSALT
• (3-amino-1-hydroxypropylidene)bis-phosphonicacidisodiumsalt
• PAMIDRONATE, DISODIUM SALT, PENTAHYDRATE
• Pamidronic Acid, Sodium Salt, Hydrate
• (3-amino-1-hydroxypropylidene)bis-phosphonic acid disodium salt
• Pamidronate Disodium, GCP-23339A, Aminomux, Aredia

Disodium Pamidronate

CAS: 109552-15-0, 40391-99-9, 57248-88-1

Formula: C₃H₉NNa₂O₇P₂

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 279.03

Ref: 3B-D3921

Pamidronate Disodium

CAS: 57248-88-1

Pamidronate Disodium (CGP 23339A), a nitrogen-containing bisphosphonate, can help to strengthen bones.

Formula: C₃H₉NNa₂O₇P₂

Purity: 99.86% - 99.93%

Color and Shape: White Crystals

Molecular weight: 279.03

Ref: TM-T1337

Disodium pamidronate hydrate

CAS: 57248-88-1

Formula: C₃H₉NNa₂O₇P₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 279.0331

Ref: IN-DA00IA7A

Pamidronate disodium salt hydrate

CAS: 57248-88-1

Pamidronate disodium salt hydrate

Purity: 98%

Molecular weight: 279.03g/mol

Ref: 54-OR1027737

Pamidronate disodium salt

CAS: 57248-88-1

Formula: C₃H₉NO₇P₂Na₂·xH₂O

Molecular weight: 279.03 (anhydrous)

Ref: 7W-GP2943

Pamidronate Disodium

CAS: 57248-88-1

Pamidronate Disodium

Purity: ≥98%

Molecular weight: 279.03g/mol

Ref: 54-BUP15429

Pamidronate Disodium

CAS: 57248-88-1

Formula: C₃H₉NO₇P₂·2Na

Molecular weight: 233.05 2 22.99

Ref: 4Z-P-294001

Pamidronic Acid Sodium Salt Hydrate

Controlled Product

CAS: 57248-88-1

Stability Hygroscopic
Applications A bisphosphonate antiresorptive agent; bone resorption inhibitor.
References Coukell, A.J., et al.: Drugs Aging, 12, 149 (1998), McTavish, D., et al.: Drugs, 41, 289 (1991), Sissons, C.H., et al.: Oral Microbiol. Immunol., 15, 317 (2000), Chen, J.X., et al.: J. Cell Physiol., 186, 116 (2001),

Formula: C₃H₉NO₇P₂·2Na·xH₂O

Color and Shape: White

Molecular weight: 279.03

Ref: TR-P172500

Sodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate xhydrate

CAS: 57248-88-1

Purity: 95.0%

Color and Shape: Solid, No data available.

Molecular weight: 297.0469970703125

Ref: 10-F431320

Pamidronic acid sodium salt hydrate

CAS: 57248-88-1

Farnesyl diphosphate synthase inhibitor

Formula: C₃H₉NNa₂O₇P₂·xH₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 279.03 g/mol

Ref: 3D-FP26745

Pamidronic acid disodium hydrate - Bio-X ™

CAS: 57248-88-1

Pamidronic acid is a bisphosphate used in the treatment of Paget’s disease, osteolytic bone lesions and in the treatment of hypercalcemia of malignancy. This drug inhibits farnesyl diphosphate and induces apoptosis of hematopoietic tumor cells.

Formula: C₃H₉NNa₂O₇P₂·4H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 351.11 g/mol

Ref: 3D-BP164229