CAS 57248-88-1: Pamidronate disodium
Description:Pamidronate disodium is a bisphosphonate compound primarily used in the treatment of conditions characterized by excessive bone resorption, such as osteoporosis and Paget's disease, as well as in managing hypercalcemia associated with malignancies. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The substance is typically administered intravenously due to its poor oral bioavailability. Pamidronate disodium is a white to off-white powder that is soluble in water, making it suitable for parenteral formulations. Its chemical structure features two phosphonate groups, which are responsible for its high affinity for bone tissue. The compound is generally well-tolerated, although it may cause side effects such as flu-like symptoms, gastrointestinal disturbances, and, in rare cases, osteonecrosis of the jaw. As with other bisphosphonates, it is essential to monitor renal function during treatment, as the drug is primarily excreted through the kidneys. Overall, pamidronate disodium plays a significant role in managing bone-related disorders.
Formula:C3H11NO7P2·2Na
InChI:InChI=1S/C3H11NO7P2.2Na/c4-2-1-3(5,12(6,7)8)13(9,10)11;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;
InChI key:InChIKey=JFDLEPOYGUTJNG-UHFFFAOYSA-N
SMILES:[Na].O=P(O)(O)C(O)(CCN)P(=O)(O)O
- Synonyms:
- 3-Amino-1-Hydroxy-1-Phosphonopropyl Phosphonic Acid Disodium Salt
- 3-Amino-1-hydroxypropane-1,1-diphosphonic acid disodium salt
- APD (pharmaceutical)
- Aminomux
- Aredia
- Cgp 23339A
- Cgp 23339Ae
- Disodium (3-Amino-1-Hydroxypropane-1,1-Diyl)Bis[Hydrogen (Phosphonate)]
- Disodium 3-amino-1-hydroxypropane-1,1-diphosphonate
- Disodium [3-amino-1-hydroxy-1-(hydroxy-oxidophosphoryl)propyl]-hydroxyphosphinate
- See more synonyms
- Pamidronate Disodium
- Pamidronate Disodium Salt
- Pamidronic acid disodium salt
- Pamimed
- Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt
- Phosphonic acid, P,P′-(3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
- phosphonate, P,P'-(3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
- APD
