CAS 57444-62-9: Resiniferatoxin

Description:Resiniferatoxin (RTX) is a potent chemical compound classified as a natural product and is derived from the resin of the plant Euphorbia resinifera, commonly known as the resin spurge. It is a highly selective agonist for the transient receptor potential vanilloid 1 (TRPV1) ion channel, which plays a crucial role in pain sensation and thermoregulation. RTX is known for its extreme potency, being significantly more effective than capsaicin, the active component in chili peppers. This compound exhibits a unique structure characterized by a long aliphatic chain and a series of functional groups that contribute to its biological activity. In research, resiniferatoxin has been studied for its potential therapeutic applications, particularly in pain management and as an analgesic, due to its ability to induce desensitization of sensory neurons. However, its use is limited by its toxicity at higher concentrations. Overall, resiniferatoxin serves as an important tool in pharmacological studies and offers insights into pain mechanisms and potential treatments.

Formula:C₃₇H₄₀O₉

InChI:InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1

InChI key:InChIKey=DSDNAKHZNJAGHN-MXTYGGKSSA-N

SMILES:O=C(OCC1=CC2C3OC4(OC3(C(=C)C)CC(C)C2(O4)C5C=C(C(=O)C5(O)C1)C)CC=6C=CC=CC6)CC7=CC=C(O)C(OC)=C7

Synonyms:
(+)-Resiniferatoxin
Benzeneacetic acid, 4-hydroxy-3-methoxy-, [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester
Benzeneacetic acid, 4-hydroxy-3-methoxy-, [3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester, [2S-(2α,3aβ,3bβ,6aβ,9aα,9bα,10α,11aβ)]-
Daphnetoxin, 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-, 20-(4-hydroxy-3-methoxybenzeneacetate)
RTX
Rtx-107
[(2R,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate
[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-11a-(prop-1-en-2-yl)-7-oxo-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate
[(3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-2-methoxyphenyl)acetate
[(3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate
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Found 5 products.

Product data	Purity	Price range	Estimated delivery
Resiniferatoxin REF: 7W-GL4270CAS: 57444-62-9	(HPLC) ≥ 98.0%	To inquire	Tue 15 Apr 25
Resiniferatoxin REF: 4Z-R-081001CAS: 57444-62-9	- - -	To inquire	Mon 21 Apr 25
Resiniferatoxin REF: 3D-FR45558CAS: 57444-62-9	Min. 95%	478.00 €~3,758.00 €	Fri 25 Apr 25
Resiniferatoxin REF: TM-T34295CAS: 57444-62-9	93.08% - 99.12%	434.00 €~1,084.00 €	Mon 02 Jun 25
Resiniferatoxin REF: 3D-J-026914CAS: 57444-62-9	(%) Min. 98.0%	- - -	Discontinued product