CAS 57444-62-9

Resiniferatoxin

Description:

Resiniferatoxin (RTX) is a potent chemical compound classified as a natural product and is derived from the resin of the plant Euphorbia resinifera, commonly known as the resin spurge. It is a highly selective agonist for the transient receptor potential vanilloid 1 (TRPV1) ion channel, which plays a crucial role in pain sensation and thermoregulation. RTX is known for its extreme potency, being significantly more effective than capsaicin, the active component in chili peppers. This compound exhibits a unique structure characterized by a long aliphatic chain and a series of functional groups that contribute to its biological activity. In research, resiniferatoxin has been studied for its potential therapeutic applications, particularly in pain management and as an analgesic, due to its ability to induce desensitization of sensory neurons. However, its use is limited by its toxicity at higher concentrations. Overall, resiniferatoxin serves as an important tool in pharmacological studies and offers insights into pain mechanisms and potential treatments.

Formula: C₃₇H₄₀O₉

InChI: InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1

InChI key: InChIKey=DSDNAKHZNJAGHN-MXTYGGKSSA-N

SMILES: C[C@H]1[C@]23[C@]([C@@]4([C@](C(C)=C)(C1)O[C@](CC5=CC=CC=C5)(O2)O4)[H])(C=C(COC(CC6=CC(OC)=C(O)C=C6)=O)C[C@@]7(O)[C@]3(C=C(C)C7=O)[H])[H]

Synonyms:

• (+)-Resiniferatoxin
• Benzeneacetic acid, 4-hydroxy-3-methoxy-, [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester
• Benzeneacetic acid, 4-hydroxy-3-methoxy-, [3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester, [2S-(2α,3aβ,3bβ,6aβ,9aα,9bα,10α,11aβ)]-
• Daphnetoxin, 6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-, 20-(4-hydroxy-3-methoxybenzeneacetate)
• RTX
• Rtx-107
• [(2R,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate
• [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-11a-(prop-1-en-2-yl)-7-oxo-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate
• [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-2-methoxyphenyl)acetate
• [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate

Resiniferatoxin

CAS: 57444-62-9

Formula: C₃₇H₄₀O₉

Purity: (HPLC) ≥ 98.0%

Color and Shape: White solid

Molecular weight: 628.71

Ref: 7W-GL4270

Resiniferatoxin

CAS: 57444-62-9

Formula: C₃₇H₄₀O₉

Molecular weight: 628.73

Ref: 4Z-R-081001

Resiniferatoxin

CAS: 57444-62-9

Resiniferatoxin is a natural chemical found in some plants that activates pain receptors.

Formula: C₃₇H₄₀O₉

Purity: Min. 98.00 Area-%

Color and Shape: White Powder

Molecular weight: 628.71 g/mol

Ref: 3D-FR45558

Resiniferatoxin

CAS: 57444-62-9

Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist.Cost-effective and quality-assured.

Formula: C₃₇H₄₀O₉

Purity: 93.08% - 99.34%

Color and Shape: Solid

Molecular weight: 628.71

Ref: TM-T34295