CAS 5746-04-3
:Nε-(Carboxymethyl)lysine
Description:
Nε-(Carboxymethyl)lysine, commonly referred to as CML, is a derivative of the amino acid lysine, characterized by the addition of a carboxymethyl group to the epsilon amino group of lysine. This compound is notable for its role as a marker of advanced glycation end products (AGEs), which are formed through the non-enzymatic reaction between sugars and proteins. CML is often studied in the context of diabetes and aging, as it is associated with oxidative stress and inflammation. It is a white to off-white solid that is soluble in water, making it suitable for various biochemical applications. The presence of the carboxymethyl group imparts acidic properties, allowing it to participate in various chemical reactions. CML is also of interest in food chemistry, as it can form during the cooking of certain foods, contributing to flavor and color changes. Its biological significance and potential implications in health and disease make it a subject of ongoing research in the fields of biochemistry and nutrition.
Formula:C8H16N2O4
InChI:InChI=1S/C8H16N2O4/c9-6(8(13)14)3-1-2-4-10-5-7(11)12/h6,10H,1-5,9H2,(H,11,12)(H,13,14)/t6-/m0/s1
InChI key:InChIKey=NUXSIDPKKIEIMI-LURJTMIESA-N
SMILES:C([C@@H](C(O)=O)N)CCCNCC(O)=O
Synonyms:- (2S)-2-Amino-6-(carboxymethylamino)hexanoic acid
- <span class="text-smallcaps">L</span>-Lysine, N<sup>6</sup>-(carboxymethyl)-
- L-Lysine,N6-(carboxymethyl)-
- Lysine, N<sup>6</sup>-(carboxymethyl)-, <span class="text-smallcaps">L</span>-
- Lysine,N6-(carboxymethyl)-, L- (8CI)
- N-(3-chloro-4-fluorophenyl)-2-[(2-chlorophenyl)sulfanyl]acetamide
- N6-(1-Carboxymethyl)-L-lysine
- N6-(Carboxymethyl)lysine
- N<sup>6</sup>-(Carboxymethyl)-<span class="text-smallcaps">L</span>-lysine
- N<sup>6</sup>-(Carboxymethyl)lysine
- N<sup>ε</sup>-(Carboxymethyl)lysine
- Ne-(Carboxymethyl)lysine
- e-(Carboxymethyl)lysine
- N6-(Carboxymethyl)-L-lysine
- See more synonyms
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Found 8 products.
(2S)-2-Amino-6-(carboxymethylamino)hexanoic acid hydrochloride
CAS:<p>(2S)-2-Amino-6-(carboxymethylamino)hexanoic acid hydrochloride</p>Purity:95%Color and Shape:SolidMolecular weight:240.68g/molNε-(1-Carboxymethyl)-L-lysine
CAS:<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>Formula:C8H16N2O4Color and Shape:NeatMolecular weight:204.22N-ε-(1-Carboxymethyl)-L-lysine
CAS:<p>N-ε-(1-Carboxymethyl)-L-lysine (NEM) is a versatile building block that is used in the synthesis of complex compounds. It is a reagent and speciality chemical that can be used as an intermediate to produce other useful chemicals or as a reaction component. It has been shown to be useful in the synthesis of peptides, oligonucleotides, and organic molecules. NEM has also been shown to have high quality and purity, making it a useful scaffold for further research into new compounds.</p>Formula:C8H16N2O4Purity:Min. 97%Color and Shape:White PowderMolecular weight:204.22 g/mol(2S)-2-amino-6-[(carboxymethyl)amino]hexanoic acid
CAS:Formula:C8H16N2O4Purity:98%Color and Shape:White crystalline powderMolecular weight:204.226Nε-(Carboxymethyl)-L-lysine-2,6,6-d3
CAS:Controlled ProductFormula:C8H13D3N2O4Color and Shape:NeatMolecular weight:207.24Nε-(1-Carboxymethyl)-L-lysine
CAS:<p>Nε-(1-Carboxymethyl)-L-lysine (CML), an advanced glycation end product (AGE), is formed through the oxidative modification of glycated proteins under conditions of oxidative stress.1,2,3 Its levels escalate with age, diabetes, cancer, vascular diseases, and various pathologies associated with oxidative stress.1,4,5 CML interacts with the membrane-bound receptor for AGEs (RAGE), initiating signaling via MAPKs and NF-κB pathways. Conversely, a truncated version of RAGE generates a soluble protein that sequesters CML, thereby diminishing this signaling.6,7</p>Formula:C8H16N2O4Color and Shape:SolidMolecular weight:204.2
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