(nle11)-Substance P, identified by the CAS number 57462-42-7, is a synthetic analog of the neuropeptide substance P, which is involved in various physiological processes, including pain perception, inflammation, and stress response. This compound is characterized by its structural modification, specifically the substitution of the amino acid leucine at position 11 with norleucine, which enhances its stability and receptor binding affinity. (nle11)-Substance P exhibits similar biological activity to the natural substance P but may have altered pharmacokinetic properties, making it of interest in research related to pain management and neurobiology. The compound interacts with neurokinin receptors, particularly the NK1 receptor, which plays a crucial role in mediating the effects of substance P. Its potential therapeutic applications are being explored in various fields, including pain relief and treatment of neurogenic inflammation. As with many peptide analogs, (nle11)-Substance P may also be subject to degradation by proteolytic enzymes, influencing its efficacy and duration of action in biological systems.

(nle11)-substance P

57462-42-7: (nle11)-Substance P, identified by the CAS number 57462-42-7, is a synthetic analog of the neuropeptide substance P, which is involved in various physiological processes, including pain perception, inflammation, and stress response. This compound is characterized by its structural modification, specifically the substitution of the amino acid leucine at position 11 with norleucine, which enhances its stability and receptor binding affinity. (nle11)-Substance P exhibits similar biological activity to the natural substance P but may have altered pharmacokinetic properties, making it of interest in research related to pain management and neurobiology. The compound interacts with neurokinin receptors, particularly the NK1 receptor, which plays a crucial role in mediating the effects of substance P. Its potential therapeutic applications are being explored in various fields, including pain relief and treatment of neurogenic inflammation. As with many peptide analogs, (nle11)-Substance P may also be subject to degradation by proteolytic enzymes, influencing its efficacy and duration of action in biological systems.

<p>'[Nle11]-Substance P is a gut and brain peptide, resisting methionine oxidation and causing excitatory neural effects.'</p>

[Nle11]-Substance P

<p>Substance P is a neurotransmitter that is involved in the transmission of pain signals to the central nervous system. It has been shown to decrease the production of nitric oxide, which leads to vasodilation and an increase in blood flow. Substance P has also been shown to have anti-aging effects on humans, and analogs have been developed for use in cosmetics.</p>

CAS 57462-42-7

(nle11)-substance P

[Nle11]-Substance P

Ref: TM-TP1831

(Nle 11)-Substance P

Ref: 3D-FN108551