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CAS 57468-17-4

:

substance P fragment 1-9

Description:
Substance P fragment 1-9, identified by the CAS number 57468-17-4, is a peptide that represents a specific segment of the neuropeptide substance P, which is involved in various physiological processes, including pain perception, inflammation, and neurogenic responses. This fragment consists of the first nine amino acids of the full substance P molecule, retaining some of its biological activity. Characteristically, it is hydrophilic due to the presence of polar amino acids, which influences its solubility in aqueous environments. The peptide is typically synthesized through solid-phase peptide synthesis and can be utilized in research to study neuropeptide signaling pathways and receptor interactions. Its biological functions are primarily mediated through the neurokinin-1 receptor, making it a subject of interest in pain management and neurobiology. Additionally, the stability and activity of this fragment can be affected by factors such as pH, temperature, and the presence of proteolytic enzymes. Overall, substance P fragment 1-9 serves as a valuable tool in understanding the complex roles of neuropeptides in the nervous system.
Formula:C52H77N15O12
InChI:InChI=1/C52H77N15O12/c53-24-8-7-17-36(63-49(77)39-18-10-26-66(39)50(78)33(54)16-9-25-59-52(57)58)51(79)67-27-11-19-40(67)48(76)62-35(21-23-42(56)69)45(73)61-34(20-22-41(55)68)46(74)65-38(29-32-14-5-2-6-15-32)47(75)64-37(44(72)60-30-43(70)71)28-31-12-3-1-4-13-31/h1-6,12-15,33-40H,7-11,16-30,53-54H2,(H2,55,68)(H2,56,69)(H,60,72)(H,61,73)(H,62,76)(H,63,77)(H,64,75)(H,65,74)(H,70,71)(H4,57,58,59)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
SMILES:c1ccc(cc1)C[C@@H](C(=NCC(=O)O)O)N=C([C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@H](CCC(=N)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C([C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O)O)O)O
Synonyms:
  • Substance P (1-9)
  • H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-OH
  • N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycine
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