CAS 57576-44-0

Aclarubicin

Description:

Aclarubicin is an anthracycline antibiotic used primarily in cancer treatment, particularly for certain types of leukemia and solid tumors. It is derived from the bacterium Streptomyces galilaeus and functions by intercalating into DNA, thereby inhibiting DNA and RNA synthesis, which ultimately leads to cell death. Aclarubicin is characterized by its red color and is soluble in water, making it suitable for intravenous administration. Its mechanism of action involves the generation of free radicals, which contribute to its cytotoxic effects. The compound has a relatively short half-life in the body, necessitating careful dosing and monitoring during treatment. Common side effects associated with Aclarubicin include myelosuppression, cardiotoxicity, and gastrointestinal disturbances. Due to its potent effects and potential toxicity, its use is often limited to specific clinical scenarios, and it is typically administered under the supervision of healthcare professionals experienced in oncology. Overall, Aclarubicin remains an important agent in the chemotherapeutic arsenal against certain malignancies.

Formula: C₄₂H₅₃NO₁₅

InChI: InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+/m0/s1

InChI key: InChIKey=USZYSDMBJDPRIF-SVEJIMAYSA-N

SMILES: C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7

Synonyms:

• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, (1R,2R,4S)-
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-<span class="text-smallcaps">L</smallcap>-lyxo-hexopyranosyl]-3-(dimethylamino)-α-<smallcap>L</span>-lyxo-hexopyranosyl]oxy]-, methyl ester, [1R-(1α,2β,4β)]-
• Aclacinomycin A
• Aclacinomycin A, Streptomycesgalilaeus
• Aclacur
• Aclarubicin
• Antibiotic 3082A
• Antibiotic 77-3082A
• Antibiotic MA 144A1
• Jaclacin
• NSC 208734
• methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-({2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-(6-methyl-5-oxotetrahydro-2H-pyran-2-yl)hexopyranosyl]-3-(dimethylamino)hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
• methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[(3xi)-2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-threo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
• methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl}-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
• 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, (1R,2R,4S)-

Aclacinomycin A

CAS: 57576-44-0

Aclacinomycin A has a wide range of applications in life science related research.

Formula: C₄₂H₅₃NO₁₅

Purity: 99.43%

Color and Shape: Solid

Molecular weight: 811.87

Ref: TM-T21502

Aclacinomycin A

CAS: 57576-44-0

Aclacinomycin A

Purity: ≥98%

Molecular weight: 811.87g/mol

Ref: 54-BUP21866

Aclacinomycin A

CAS: 57576-44-0

Formula: C₄₂H₅₃NO₁₅

Purity: ≥ 90.%

Color and Shape: Yellow to orange powder or solid

Molecular weight: 811.87

Ref: 7W-GC6221

Aclarubicin

CAS: 57576-44-0

Formula: C₄₂H₅₃NO₁₅

Molecular weight: 811.88

Ref: 4Z-A-243001

Aclarubicin

Controlled Product

CAS: 57576-44-0

Applications Aclarubicin is an anthracycline antibiotic. It is used in the treatment of cancer.
References Magi, S., et al.: J. Antibiot., 66, 165 (2013); Wakabayashi, I., et al.: Biochem. Pharmacol., 59, 719 (2000); Viadro, M., et al.: Antibiot Khimioter, 36, 20 (1991);

Formula: C₄₂H₅₃NO₁₅

Color and Shape: Dark Yellow Solid

Molecular weight: 811.87

Ref: TR-A190160

Aclacinomycin A

CAS: 57576-44-0

Dual inhibitor of topoisomerase I and II

Formula: C₄₂H₅₃NO₁₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 811.87 g/mol

Ref: 3D-AA08264

Aclarubicin-13CD3

Controlled Product

CAS: 57576-44-0

Formula: CC₄₁D₃H₅₀NO₁₅

Color and Shape: Neat

Molecular weight: 815.879

Ref: TR-A190162

Aclarubicin

CAS: 57576-44-0

Formula: C₄₂H₅₃NO₁₅

Molecular weight: 811.88

Ref: ST-EA-CP-A302000

Aclarubicin-13C-d3

CAS: 57576-44-0

Formula: C₄₁₁₃CH₅₀D₃NO₁₅

Molecular weight: 815.89

Ref: 4Z-A-243002