CymitQuimica logo

CAS 57576-52-0

:

Thromboxane A2

Description:
Thromboxane A2 (TXA2) is a potent lipid mediator that plays a crucial role in hemostasis and vascular biology. It is a member of the eicosanoid family, derived from arachidonic acid through the action of cyclooxygenase enzymes. TXA2 is primarily produced by activated platelets and is known for its ability to promote platelet aggregation and vasoconstriction, thereby contributing to the formation of blood clots. Structurally, it is characterized by a cyclic ether and a ketone functional group, which are essential for its biological activity. TXA2 has a very short half-life, typically measured in seconds, due to its rapid conversion to thromboxane B2 (TXB2), an inactive metabolite. Its actions are mediated through specific thromboxane receptors, which are G protein-coupled receptors found on various cell types. Dysregulation of TXA2 production or signaling can be implicated in various cardiovascular diseases, making it a target for therapeutic interventions. Overall, thromboxane A2 is a critical player in the regulation of vascular tone and platelet function.
Formula:C20H32O5
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1
InChI key:InChIKey=DSNBHJFQCNUKMA-SCKDECHMSA-N
SMILES:C(/C=C\CCCC(O)=O)[C@H]1[C@@]2(C[C@@](O2)(O[C@@H]1/C=C/[C@H](CCCCC)O)[H])[H]
Synonyms:
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-heptenoic acid
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoic acid
  • (5Z,9a,11a,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic Acid
  • (5Z,9alpha,11alpha,13E,15S)-9,11-epoxy-15-hydroxy-Thromboxa-5,13-dien-1-oic acid
  • 5-Heptenoic acid, 7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-, (5Z)-
  • 5-Heptenoic acid, 7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-, (5Z)-
  • 5-Heptenoic acid, 7-[3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo[3.1.1]hept-4-yl]-, [1S-[1α,3α(1E,3R*),4β(Z),5α]]-
  • 57576-52-0
  • TXA<sub>2</sub>
  • Thromboxa-5,13-dien-1-oic acid, 9,11-epoxy-15-hydroxy-, (5Z,9α,11α,13E,15S)-
  • See more synonyms
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 3 products.