CAS 57648-21-2

Timiperone

Description:

Timiperone is an antipsychotic medication primarily used in the treatment of schizophrenia and other related disorders. It belongs to the class of butyrophenones, which are characterized by their ability to antagonize dopamine receptors, particularly the D2 subtype. This action helps to alleviate symptoms of psychosis, such as hallucinations and delusions. Timiperone is known for its relatively low incidence of extrapyramidal side effects compared to other antipsychotics, making it a preferred choice in certain clinical scenarios. The substance exhibits a moderate affinity for serotonin receptors as well, which may contribute to its therapeutic effects. Timiperone is typically administered in oral form and is metabolized in the liver, with its pharmacokinetics influenced by various factors including age and liver function. As with many antipsychotic medications, monitoring for potential side effects, including metabolic changes and sedation, is essential during treatment. Overall, Timiperone represents a valuable option in the pharmacological management of schizophrenia, balancing efficacy with a favorable side effect profile.

Formula: C₂₂H₂₄FN₃OS

InChI: InChI=1S/C22H24FN3OS/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)

InChI key: InChIKey=YDLQKLWVKKFPII-UHFFFAOYSA-N

SMILES: S=C1N(C=2C(N1)=CC=CC2)C3CCN(CCCC(=O)C4=CC=C(F)C=C4)CC3

Synonyms:

• 1-(4-Fluorophenyl)-4-[4-(2-thioxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
• 1-[1-[3-(4-Fluorobenzoyl)propyl]-4-piperidyl]-2,3-dihydrobenzimidazole-2-thione
• 1-[1-[3-(4-Fluorobenzoyl)propyl]-4-piperidyl]-2-mercaptobenzimidazole
• 1-butanone, 4-[4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-
• 260-880-9
• 4-Fluoro-4-[4-(2-thioxo-1-benzimidazolinyl)piperidino]butyrophenone
• 4-[4-(2,3-Dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
• Celmanil
• Dd 3480
• Timeperone
• Tolopelon

Timiperone

CAS: 57648-21-2

Applications Butyrophenone derivative having neuroleptic activity, used as an antipsychotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shimoda, K., et al.: Pharmacol. Toxicol., 83, 164 (1998), Sekine, Y., et al.: Eur. J. Clin. Pharmacol., 55, 583 (1999), Oka, T., et al.: Life Sci., 76, 225 (2004), Fujikawa, M., et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 32, 755 (2008),

Formula: C₂₂H₂₄FN₃OS

Color and Shape: Neat

Molecular weight: 397.51

Ref: TR-T443110

Timiperone

CAS: 57648-21-2

Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.

Formula: C₂₂H₂₄FN₃OS

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.51

Ref: TM-T78514