CAS 57773-63-4

Triptorelin

Description:

Triptorelin is a synthetic peptide and a gonadotropin-releasing hormone (GnRH) analog, primarily used in the treatment of hormone-sensitive conditions such as prostate cancer, endometriosis, and precocious puberty. It is characterized by its ability to inhibit the secretion of gonadotropins (LH and FSH) from the pituitary gland, leading to a decrease in testosterone and estrogen levels. Triptorelin is typically administered via injection and has a prolonged action compared to natural GnRH due to its structural modifications, which enhance its stability and bioavailability. The substance is known for its efficacy in managing hormone-related disorders, but it may also have side effects, including hot flashes, mood changes, and potential impacts on bone density with long-term use. Its chemical structure includes a sequence of amino acids that mimic the natural hormone, allowing it to bind effectively to GnRH receptors. As a therapeutic agent, Triptorelin is classified under the category of hormonal therapies and is subject to regulation in various medical contexts.

Formula: C₆₆H₈₈N₁₈O₁₅

InChI: InChI=1/C42H59N11O9.C22H25N7O4.C2H4O2/c1-24(2)19-31(37(58)50-30(9-5-16-46-42(44)45)41(62)53-17-6-10-34(53)40(61)48-23-35(43)56)51-39(60)33(21-26-22-47-29-8-4-3-7-28(26)29)52-38(59)32(49-36(57)15-18-54)20-25-11-13-27(55)14-12-25;23-20(31)17(7-12-9-25-15-4-2-1-3-14(12)15)28-22(33)18(8-13-10-24-11-26-13)29-21(32)16-5-6-19(30)27-16;1-2(3)4/h3-4,7-8,11-14,22,24,30-34,47,54-55H,5-6,9-10,15-21,23H2,1-2H3,(H2,43,56)(H,48,61)(H,49,57)(H,50,58)(H,51,60)(H,52,59)(H4,44,45,46);1-4,9-11,16-18,25H,5-8H2,(H2,23,31)(H,24,26)(H,27,30)(H,28,33)(H,29,32);1H3,(H,3,4)/t30-,31-,32-,33+,34-;16-,17-,18-;/m00./s1

(D-Trp⁶)-LHRH

CAS: 57773-63-4

A long-acting GnRH agonist. Pamoate is the bivalent anion of pamoic acid (embonic acid, 4,4·-methylene-bis-(3-hydroxy-2-naphthoic acid)). CAS-number (triptorelin pamoate) 124508-66-3.

Formula: C₆₄H₈₂N₁₈O₁₃

Purity: 99.09%

Color and Shape: Light Yellow

Molecular weight: 1311.47

Ref: 01-4039648

(D-Trp⁶)-LHRH

CAS: 57773-63-4

LHRH agonist used in the treatment of prostate cancer. Triptorelin decreases the secretion of LH and FSH. CAS-number (triptorelin acetate) 140194-24-7.

Formula: C₆₄H₈₂N₁₈O₁₃

Purity: 99.2%

Color and Shape: Whitish

Molecular weight: 1311.47

Ref: 01-4033016

Triptorelin Acetate (5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycinamide acetate salt)

CAS: 57773-63-4

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₆₄H₈₂N₁₈O₁₃·C₂H₄O₂

Color and Shape: White Powder

Molecular weight: 1370.652

Ref: 45-1696131

Triptorelin Acetate

CAS: 57773-63-4

Ref: 7W-GX8805

Triptorelin-d4 Trifluoroacetate (Mixture of Isomers)

CAS: 57773-63-4

Formula: C₆₄H₇₈D₄N₁₈O₁₃·C₂HF₃O₂

Molecular weight: 1315.50 114.02

Ref: 4Z-PT-146002

Triptorelin-d7 Ditrifluoroacetate

CAS: 57773-63-4

Formula: C₆₄H₇₅D₇N₁₈O₁₃·2C₂HF₃O₂

Molecular weight: 1318.52 2*114.02

Ref: 4Z-PT-146015

Triptorelin ([DTrp6]-LH-RH)

CAS: 57773-63-4

Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferationIn vivo: (1) Triptorelin can improve the pregnancy rate by 12% to 15% in ewes6 and downregulate ovarian GnRHR-I expression of female rats, especially in late-growing follicles.(2) Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.
[1]. Wei S et al. Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR of mice. Immunopharmacol Immunotoxicol. 2016 Jun;38(3):197-204.

Formula: C₆₄H₈₂N₁₈O₁₃

Color and Shape: Powder

Molecular weight: 1311.45

Ref: TM-T36371

Triptorelin

CAS: 57773-63-4

Formula: C₆₄H₈₂N₁₈O₁₃

Color and Shape: White To Off-White Solid

Molecular weight: 1311.47

Ref: 4Z-PT-146001

Triptorelin Acetate

CAS: 57773-63-4

Formula: C₆₄H₈₂N₁₈O₁₃

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1311.45

Ref: BP-BPPG067

Triptorelin Trifluoroacetic Acid Salt-d5

Controlled Product

CAS: 57773-63-4

Applications Labelled synthetic peptide agonist analog of LH-RH. Triptoreline is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility.
References Sanders, L., et al.: Eur. J. Drug Metab. Pharmacokinet., 15, 95 (1990), Chiba, M., et al.: Biomaterials, 18, 893 (1997), Blanco, D., et al.: Eur. J. Pharm. Biopharm., 45, 285 (1998), Sinha, V., et al.: J. Control. Rel., 90, 261 (2003),

Formula: C₆₄H₇₇D₅N₁₈O₁₃x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 1316.4811402

Ref: TR-T815802

Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-

CAS: 57773-63-4

Formula: C₆₄H₈₂N₁₈O₁₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 1311.4487

Ref: IN-DA01DQA5