RNA Polymerase III Inhibitor, with the CAS number 577784-91-9, is a chemical compound that specifically targets and inhibits the activity of RNA polymerase III, an enzyme crucial for the transcription of small RNA molecules, including tRNA and 5S rRNA. This inhibition can disrupt the synthesis of these essential RNA components, potentially affecting protein synthesis and cellular function. The compound is often studied in the context of cancer research, as it may have therapeutic implications by selectively targeting cancer cells that rely heavily on RNA polymerase III activity for their growth and proliferation. Characteristically, RNA Polymerase III Inhibitors may exhibit properties such as moderate to high solubility in organic solvents, stability under physiological conditions, and a specific mechanism of action that can vary among different inhibitors. Additionally, they may have a defined pharmacokinetic profile, influencing their absorption, distribution, metabolism, and excretion in biological systems. Overall, the study of such inhibitors contributes to the understanding of gene expression regulation and the development of novel therapeutic strategies.

ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from?S. Cerevisiae?as well as from human cells, IC50=32?mM and 27?mM respectively.1?? Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2

RNA Polymerase III Inhibitor

577784-91-9: RNA Polymerase III Inhibitor, with the CAS number 577784-91-9, is a chemical compound that specifically targets and inhibits the activity of RNA polymerase III, an enzyme crucial for the transcription of small RNA molecules, including tRNA and 5S rRNA. This inhibition can disrupt the synthesis of these essential RNA components, potentially affecting protein synthesis and cellular function. The compound is often studied in the context of cancer research, as it may have therapeutic implications by selectively targeting cancer cells that rely heavily on RNA polymerase III activity for their growth and proliferation. Characteristically, RNA Polymerase III Inhibitors may exhibit properties such as moderate to high solubility in organic solvents, stability under physiological conditions, and a specific mechanism of action that can vary among different inhibitors. Additionally, they may have a defined pharmacokinetic profile, influencing their absorption, distribution, metabolism, and excretion in biological systems. Overall, the study of such inhibitors contributes to the understanding of gene expression regulation and the development of novel therapeutic strategies.

ML-60218

<p>ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.</p>

CAS 577784-91-9

RNA Polymerase III Inhibitor

ML-60218

Ref: 54-BUP05223

ML-60218

Ref: TM-T40661