CAS 577784-91-9

RNA Polymerase III Inhibitor

Description:

RNA Polymerase III Inhibitor, with the CAS number 577784-91-9, is a chemical compound that specifically targets and inhibits the activity of RNA polymerase III, an enzyme crucial for the transcription of small RNA molecules, including tRNA and 5S rRNA. This inhibition can disrupt the synthesis of these essential RNA components, potentially affecting protein synthesis and cellular function. The compound is often studied in the context of cancer research, as it may have therapeutic implications by selectively targeting cancer cells that rely heavily on RNA polymerase III activity for their growth and proliferation. Characteristically, RNA Polymerase III Inhibitors may exhibit properties such as moderate to high solubility in organic solvents, stability under physiological conditions, and a specific mechanism of action that can vary among different inhibitors. Additionally, they may have a defined pharmacokinetic profile, influencing their absorption, distribution, metabolism, and excretion in biological systems. Overall, the study of such inhibitors contributes to the understanding of gene expression regulation and the development of novel therapeutic strategies.

Formula: C₁₉H₁₅Cl₂N₃O₂S₂

Synonyms:

• InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
• RNA Polymerase III Inhibitor
• Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-
• RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
• 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide

ML-60218

CAS: 577784-91-9

ML-60218

Formula: C₁₉H₁₅Cl₂N₃O₂S₂

Purity: ≥98%

Molecular weight: 452.38

Ref: 54-BUP05223

ML-60218

CAS: 577784-91-9

ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.

Formula: C₁₉H₁₅Cl₂N₃O₂S₂

Purity: 98.1%

Color and Shape: Solid

Molecular weight: 452.38

Ref: TM-T40661

ML-60218

CAS: 577784-91-9

2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide

Formula: C₁₉H₁₅Cl₂N₃O₂S₂

Purity: 98%

Molecular weight: 452.38

Ref: IN-DG01208914