CAS 5778-80-3

7-Methoxytacrine

Description:

7-Methoxytacrine, also known by its CAS number 5778-80-3, is a synthetic compound that belongs to the class of tacrine derivatives. It is primarily recognized for its potential use in the treatment of neurodegenerative diseases, particularly Alzheimer's disease, due to its ability to inhibit acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. This inhibition can enhance cholinergic neurotransmission, which is often impaired in Alzheimer's patients. The compound features a methoxy group at the 7-position of the tacrine structure, which contributes to its pharmacological properties. In terms of physical characteristics, 7-Methoxytacrine is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. Its chemical structure includes a fused bicyclic system, which is characteristic of tacrine derivatives. As with many compounds in this class, research continues to explore its efficacy, safety, and potential side effects in clinical applications.

Formula: C₁₄H₁₆N₂O

InChI: InChI=1S/C14H16N2O/c1-17-9-6-7-13-11(8-9)14(15)10-4-2-3-5-12(10)16-13/h6-8H,2-5H2,1H3,(H2,15,16)

InChI key: InChIKey=APQPVVOYBLOJDY-UHFFFAOYSA-N

SMILES: NC=1C=2C(N=C3C1CCCC3)=CC=C(OC)C2

Synonyms:

• 1,2,3,4-Tetrahydro-7-methoxy-9-acridinamine
• 7-Meota
• 7-Methoxy-1,2,3,4-Tetrahydroacridin-9-Amine
• 7-Methoxy-1,2,3,4-tetrahydro-9-acridinamine
• 7-Methoxytacrine
• 9-Acridinamine, 1,2,3,4-tetrahydro-7-methoxy-
• Acridine, 9-amino-1,2,3,4-tetrahydro-7-methoxy-
• 9-Amino-7-methoxy-1,2,3,4-tetrahydroacridine

TA-03

CAS: 5778-80-3

TA-03

Purity: ≥98%

Molecular weight: 228.29g/mol

Ref: 54-BUP09368

TA-03

CAS: 5778-80-3

TA-03 (7-Meota) is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.

Formula: C₁₄H₁₆N₂O

Purity: 99.22%

Color and Shape: Solid

Molecular weight: 228.29

Ref: TM-T8585

7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine

CAS: 5778-80-3

7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine is a cholinergic drug that is used to treat high blood pressure. It blocks the action of acetylcholinesterase, which breaks down acetylcholine in the synaptic cleft. 7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine also has been shown to have an inhibitory effect on red blood cells and may be used as a treatment for dyskinesias. 7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine has a pharmacokinetic study with animal models. The results show that 7MA penetrates the blood brain barrier more easily than other cholinergic drugs. This drug also shows an inhibitory effect on Alzheimer's disease and is active against cholinesterase inhibitors such

Formula: C₁₄H₁₆N₂O

Purity: Min. 95%

Molecular weight: 228.29 g/mol

Ref: 3D-FAA77880