CAS 578-76-7
:7-Methylguanine
Description:
7-Methylguanine is a modified nucleobase that plays a significant role in the structure and function of nucleic acids. It is a derivative of guanine, where a methyl group is attached to the nitrogen atom at the 7-position of the purine ring. This modification can influence the stability and pairing properties of nucleic acids, particularly in RNA, where it is often found in the cap structure of mRNA, contributing to mRNA stability and translation efficiency. The presence of 7-methylguanine can also affect gene expression and cellular processes. In terms of physical properties, it is typically a white to off-white crystalline solid, soluble in water and organic solvents. Its molecular formula is C6H7N5O, and it has a molecular weight that reflects its composition of carbon, hydrogen, nitrogen, and oxygen. 7-Methylguanine is of interest in biochemical research and has implications in studies related to epigenetics and the regulation of gene expression.
Formula:C6H7N5O
InChI:InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)
InChI key:InChIKey=FZWGECJQACGGTI-UHFFFAOYSA-N
SMILES:O=C1C2=C(NC(N)=N1)N=CN2C
Synonyms:- 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
- 2-Amino-7-methyl-1H-purin-6(7H)-one
- 2-Amino-7-methyl-3H-purin-6-one
- 2-Amino-7-methyl-6,7-dihydro-1H-purin-6-one
- 2-Amino-7-methyl-6,7-dihydro-3H-purin-6-one
- 2-Amino-7-methyl-7H-purin-6-ol
- 2-Amino-7-methylhypoxanthine
- 2-Imino-7-methyl-2,3,6,7-tetrahydro-1H-purin-6-one
- 2-amino-7-methyl-3,7-dihydro-6H-purin-6-one
- 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
- Guanine, 7-methyl-
- N(sup 7)-Methylguanine
- N7-Methylguanine
- N<sup>7</sup>-Methylguanine
- NSC 19647
- Nsc 193444
- See more synonyms
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Found 9 products.
7-Methylguanine
CAS:Formula:C6H7N5OPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:165.166H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
CAS:Formula:C6H7N5OPurity:95%Color and Shape:SolidMolecular weight:165.15277-Methylguanine
CAS:7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, anticancer. a natural nucleic acid metabolite.Formula:C6H7N5OPurity:99.99%Color and Shape:SolidMolecular weight:165.157-Methylguanine
CAS:<p>Applications Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.<br>References Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)<br></p>Formula:C6H7N5OColor and Shape:White PowderMolecular weight:165.157-Methylguanine
CAS:<p>Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, top</p>Formula:C6H7N5OPurity:Min. 95 Area-%Color and Shape:Slightly Brown PowderMolecular weight:165.15 g/mol
