CAS 57817-83-1

N-methyl-2'-O-methyladenosine

Description:

N-methyl-2'-O-methyladenosine is a modified nucleoside derived from adenosine, characterized by the presence of a methyl group at the nitrogen atom of the purine base and a methoxy group at the 2' position of the ribose sugar. This modification can influence the stability and functionality of RNA molecules, particularly in the context of post-transcriptional modifications. N-methyl-2'-O-methyladenosine is known to play a role in various biological processes, including RNA splicing, translation, and the regulation of gene expression. Its presence can affect the interaction of RNA with proteins and other nucleic acids, potentially impacting cellular processes. The compound is of interest in research related to RNA biology and therapeutic applications, as modifications like these can enhance the pharmacological properties of RNA-based drugs. Additionally, its unique structure may provide insights into the mechanisms of RNA modification and the development of novel RNA-targeting therapies.

Formula: C₁₂H₁₇N₅O₄

InChI: InChI=1/C12H17N5O4/c1-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20-2)8(19)6(3-18)21-12/h4-6,8-9,12,18-19H,3H2,1-2H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1

SMILES: CNc1c2c(ncn1)n(cn2)[C@H]1[C@@H]([C@@H]([C@@H](CO)O1)O)OC

N6-Methyl-2'-O-methyladenosine

CAS: 57817-83-1

N6-Methyl-2'-O-methyladenosine

Purity: ≥98%

Molecular weight: 295.29g/mol

Ref: 54-BUP05343

N6,O2'-Dimethyladenosine

Controlled Product

CAS: 57817-83-1

Applications N6,O2'-Dimethyladenosine is naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Formula: C₁₂H₁₇N₅O₄

Color and Shape: White To Off White

Molecular weight: 295.29

Ref: TR-D447415

N6-Methyl-2'-O-methyladenosine

CAS: 57817-83-1

N6-Methyl-2'-O-methyladenosine (N6,2′-O-Dimethyladenosine), a substrate for adiposity and obesity-related genes (FTO), is a reversible modifier compound found

Formula: C₁₂H₁₇N₅O₄

Purity: 99.97%

Color and Shape: Solid

Molecular weight: 295.29

Ref: TM-TNU0355

N6-Methyl-2'-O-methyladenosine

CAS: 57817-83-1

N6-Methyl-2'-O-methyladenosine is a nucleoside that is found in DNA. In some cases, the methyl group in this molecule can be modified, which can change its biological activity. N6-Methyl-2'-O-methyladenosine has been shown to reduce the severity of bowel disease and myocardial infarcts in experimental models. The structural analysis of vessels from patients with atherosclerosis revealed that this molecule inhibits vascular calcification. It also decreases expression of MMP-9, a protein involved in nephropathy and diabetic kidney disease. N6-Methyl-2'-O-methyladenosine is able to inhibit the development of vascular injury by blocking the activation of cells and reducing inflammation through pharmacological agents that are used in experimental models for blood vessel injury.

Formula: C₁₂H₁₇N₅O₄

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 295.29 g/mol

Ref: 3D-NM157460

N6,O2'-Dimethyladenosine-d3

Controlled Product

CAS: 57817-83-1

Applications N6,O2'-Dimethyladenosine-d3 is an isotopic analog of N6,O2'-Dimethyladenosine (D447415), a naturally occurring modified nucleoside in RNA. It was reported in the preparation of alkylated adenosines as antihypertensive agents.
References Yamada, T., Kageyama, K.: Eur. Pat. Appl. (1988), EP 269574 A2 19880601; Aduri, R., et al.: J. Chem. Theory Comput., 3, 1464 (2007);

Formula: C₁₂H₁₄D₃N₅O₄

Color and Shape: Neat

Molecular weight: 298.31

Ref: TR-D447417

N6,O2-Dimethyladenosine

CAS: 57817-83-1

Formula: C₁₂H₁₇N₅O₄

Molecular weight: 295.3

Ref: ST-EA-CP-A88076