CAS 57852-57-0

Idarubicin hydrochloride

Description:

Idarubicin hydrochloride is an anthracycline antibiotic and an antineoplastic agent primarily used in cancer chemotherapy. It is characterized by its ability to intercalate DNA, thereby inhibiting topoisomerase II and disrupting the replication and transcription processes of cancer cells. This compound is typically administered intravenously and is known for its efficacy against various hematological malignancies, including acute myeloid leukemia and certain types of lymphoma. Idarubicin hydrochloride exhibits a red-orange color and is soluble in water, which facilitates its use in clinical settings. Its mechanism of action involves the generation of free radicals, contributing to its cytotoxic effects. However, like many chemotherapeutic agents, it is associated with potential side effects, including cardiotoxicity, myelosuppression, and gastrointestinal disturbances. Monitoring and management of these adverse effects are crucial during treatment. Overall, idarubicin hydrochloride remains a vital component in the oncological pharmacotherapy arsenal, particularly for aggressive blood cancers.

Formula: C₂₆H₂₇NO₉·ClH

InChI: InChI=1S/C26H27NO9.ClH/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31;/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3;1H/t10-,15-,16-,17-,21+,26-;/m0./s1

InChI key: InChIKey=JVHPTYWUBOQMBP-RVFAQHLVSA-N

SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4)C[C@](C(C)=O)(O)C1)[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5.Cl

Synonyms:

• (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
• (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
• (7S-cis)-9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxynaphthacene-5,12-dione hydrochloride
• 4-DMD HCl
• 4-Demethoxydaunorubicin hydrochloride
• 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-
• 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride, (7S,9S)-
• 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride, (7S-cis)-
• Idamycin
• Idarubicin Hydrochloride
• NSC 256439
• Zavedos
• 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride, (7S,9S)-
• 5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-

Idarubicin Hydrochloride

CAS: 57852-57-0

Antibiotics nesoi

Formula: C₂₆H₂₇NO₉·HCl

Color and Shape: Red Orange Reddish-Brown Powder

Molecular weight: 533.14526

Ref: 45-1335701

Idarubicin hydrochloride

CAS: 57852-57-0

Formula: C₂₆H₂₈ClNO₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 533.9548

Ref: IN-DA019FT5

Idarubicin hydrochloride

CAS: 57852-57-0

Idarubicin hydrochloride

Purity: ≥98%

Molecular weight: 533.95g/mol

Ref: 54-BUP06762

(7S,9S)-9-Acetyl-7-(((2R,4S,5S,6S)-4-Amino-5-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-Yl)Oxy)-6,9,11-Trihydroxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione Hydrochloride

CAS: 57852-57-0

(7S,9S)-9-Acetyl-7-(((2R,4S,5S,6S)-4-Amino-5-Hydroxy-6-Methyltetrahydro-2H-Pyran-2-Yl)Oxy)-6,9,11-Trihydroxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione Hydrochloride

Purity: 98%

Molecular weight: 533.95g/mol

Ref: 54-OR1023333

Idarubicin hydrochloride

CAS: 57852-57-0

Formula: C₂₆H₂₇NO₉·HCl

Purity: ≥ 98.0%

Color and Shape: Orange powder

Molecular weight: 533.95

Ref: 7W-GP2667

Idarubicin hydrochloride

CAS: 57852-57-0

Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).

Formula: C₂₆H₂₇NO₉·HCl

Purity: 98.91% - 99.96%

Color and Shape: Solid

Molecular weight: 533.95

Ref: TM-T6010

Idarubicin Hydrochloride

Controlled Product

CAS: 57852-57-0

Stability Hygroscopic, Light Sensitive
Applications Orally active anthracycline; analog of Daunorubicin. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976), Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986), Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987), Villani, F., et al.: Eur. J. Cancer Clin. Oncol., 25, 13 (1989),

Formula: C₂₆H₂₇NO₉·ClH

Color and Shape: Neat

Molecular weight: 533.95

Ref: TR-I167000

Idarubicin hydrochloride

CAS: 57852-57-0

Topoisomerase II inhibitor; daunorubicin analog; anti-leukemic; anthracycline

Formula: C₂₆H₂₈ClNO₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 533.95 g/mol

Ref: 3D-FI24535

Idarubicin Hydrochloride

CAS: 57852-57-0

Purity: ≥98%

Molecular weight: 533.960022

Ref: 10-F864036

Idarubicin Hydrochloride (10 mg/mL in DMSO)

CAS: 57852-57-0

Formula: C₂₆H₂₇NO₉·ClH

Color and Shape: Colourless

Molecular weight: 533.95

Ref: TR-KIT5376

Idarubicin Hydrochloride (1 mg/mL in DMSO)

CAS: 57852-57-0

Formula: C₂₆H₂₇NO₉·ClH

Color and Shape: Colourless

Molecular weight: 533.95

Ref: TR-KIT4161