CAS 5786-21-0
:Clozapine
Description:
Clozapine is an atypical antipsychotic medication primarily used to treat schizophrenia, particularly in patients who are resistant to other treatments. It is known for its unique mechanism of action, which involves antagonism of various neurotransmitter receptors, including dopamine D4 and serotonin 5-HT2A receptors, contributing to its efficacy in alleviating psychotic symptoms. Clozapine is characterized by its relatively low propensity to cause extrapyramidal side effects compared to typical antipsychotics, making it a valuable option for treatment-resistant cases. However, it is associated with a risk of agranulocytosis, a potentially severe decrease in white blood cell count, necessitating regular blood monitoring. The substance is typically administered orally and has a complex pharmacokinetic profile, with a long half-life and extensive metabolism primarily in the liver. Clozapine's chemical structure includes a dibenzodiazepine core, which is integral to its pharmacological properties. Overall, while effective, its use requires careful management due to the associated risks and side effects.
Formula:C18H19ClN4
InChI:InChI=1/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key:InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N
SMILES:CN1CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1
Synonyms:- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
- 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- Apo-Clozapine
- Asaleptin
- Azaleptin
- Azaleptine
- Brn 0764984
- Ccris 9171
- Clorazil
- Cloril
- Clozapex
- Clozapin
- Clozapina
- Clozapina [INN-Spanish]
- Clozapinum
- Clozapinum [INN-Latin]
- Clozaril
- Fazaclo
- Fazaclo ODT
- Hf-1854
- Hsdb 6478
- Iprox
- Klozapol
- Leponex
- Lx 100-129
- Sizopin
- Unii-J60Ar2Ikic
- W-801
- Clozapine
- e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(
- CLOZAPINE ATYPICAL NEUROLEPTIC
- LIPONEX
- Lepotex
- COLZARIL
- 8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(e)(1,4)diazepine
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 25 products.
Clozapine
CAS:Formula:C18H19ClN4Purity:>98.0%(GC)(T)Color and Shape:Light yellow to Amber to Dark green powder to crystalMolecular weight:326.83Clozapine, 97%
CAS:<p>Potent, selective muscarinic antagonist</p>Formula:C18H19Cl4Purity:97%Molecular weight:326.83Clozapine
CAS:ClozapineFormula:C18H19ClN4Purity:99.9%Color and Shape:Off-WhiteMolecular weight:326.12982CLOZAPINE FOR PEAK IDENTIFICATION CRS
CAS:<p>CLOZAPINE FOR PEAK IDENTIFICATION CRS</p>Formula:C18H19ClN4Molecular weight:326.8233Clozapine
CAS:<p>Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure</p>Formula:C18H19ClN4Color and Shape:Yellow PowderMolecular weight:326.12982Clozapine Resolution Mixture
CAS:<p>Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure</p>Color and Shape:Yellow Crystalline PowderMolecular weight:203.09061Clozapine
CAS:<p>Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent.</p>Formula:C18H19ClN4Purity:99.91% - 99.93%Color and Shape:Yellow Crystals From Acetone-Petroleum Ether SolidMolecular weight:326.82Clozapine
CAS:Formula:C18H19Cl4Purity:≤ 0.3%Color and Shape:Yellow crystalline powderMolecular weight:326.83Clozapine-d4 (4-methyl-piperazinyl-2,2,6,6-d4)
CAS:Purity:99 atom % DColor and Shape:Yellow SolidMolecular weight:330.85Clozapine
CAS:Controlled Product<p>Applications An antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>Formula:C18H19ClN4Color and Shape:Off-WhiteMolecular weight:326.82Clozapine - Bio-X ™
CAS:Controlled Product<p>Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, 5-HT2A-C, 5-HT6, 5-HT7), alpha 1 and 2 adrenergic, histamine 1 and M1-M5 muscarinic receptors. In particular, its partial 5-HT1A agonist behaviour, its low affinity for the D2 Dopamine receptors and its antagonistic activity at 5-HT2A receptors, are properties, which make it useful as an antipsychotic drug. The FDA has approved Clozapine for use in the alleviation of symptoms in treatment-resistant schizophrenia patients, such as the risk of self-harm. Although not yet approved by the FDA, Clozapione exerts positive effects in Parkinson’s disease and bipolar disorder treatments. However, Clozapione is not currently a first line-therapy option, as it may cause agranulocytosis and other side effects such as orthostatic hypotension and hypersalivation.</p>Formula:C18H19ClN4Purity:Min. 95%Color and Shape:Yellow PowderMolecular weight:326.82 g/molClozapine
CAS:Controlled Product<p>Partial 5-HT1A agonist; adrenergic, cholinergic, and histaminergic antagonist</p>Formula:C18H19ClN4Purity:Min. 97.5 Area-%Color and Shape:Yellow PowderMolecular weight:326.82 g/mol5-Acetyl-8-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one
CAS:Formula:C15H11ClN2O2Color and Shape:NeatMolecular weight:286.713
![5-Acetyl-8-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb%2FA603883.jpg&w=3840&q=75)