CAS 5786-21-0: Clozapine

Description: Clozapine is an atypical antipsychotic medication primarily used to treat schizophrenia, particularly in patients who are resistant to other treatments. It is known for its unique mechanism of action, which involves antagonism of various neurotransmitter receptors, including dopamine D4 and serotonin 5-HT2A receptors, contributing to its efficacy in alleviating psychotic symptoms. Clozapine is characterized by its relatively low propensity to cause extrapyramidal side effects compared to typical antipsychotics, making it a valuable option for treatment-resistant cases. However, it is associated with a risk of agranulocytosis, a potentially severe decrease in white blood cell count, necessitating regular blood monitoring. The substance is typically administered orally and has a complex pharmacokinetic profile, with a long half-life and extensive metabolism primarily in the liver. Clozapine's chemical structure includes a dibenzodiazepine core, which is integral to its pharmacological properties. Overall, while effective, its use requires careful management due to the associated risks and side effects.

Formula: C₁₈H₁₉ClN₄

InChI: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key: InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N

SMILES: ClC1=CC=C2NC=3C=CC=CC3C(=NC2=C1)N4CCN(C)CC4

Synonyms:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
• 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
• 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• Apo-Clozapine
• Asaleptin
• Azaleptin
• Azaleptine
• Brn 0764984
• Ccris 9171
• Clorazil
• Cloril
• Clozapex
• Clozapin
• Clozapina
• Clozapina [INN-Spanish]
• Clozapinum
• Clozapinum [INN-Latin]
• Clozaril
• Fazaclo
• Fazaclo ODT
• Hf-1854
• Hsdb 6478
• Iprox
• Klozapol
• Leponex
• Lx 100-129
• Sizopin
• Unii-J60Ar2Ikic
• W-801
• Clozapine

Clozapine - Bio-X ™

CAS: 5786-21-0

Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, …

• Formula: C₁₈H₁₉ClN₄
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 326.82 g/mol

5-Acetyl-8-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one

CAS: 5786-21-0

• Formula: C₁₅H₁₁ClN₂O₂
• Color and Shape: Neat
• Molecular weight: 286.713