CAS 5786-21-0

Clozapine

Description:

Clozapine is an atypical antipsychotic medication primarily used to treat schizophrenia, particularly in patients who are resistant to other treatments. It is known for its unique mechanism of action, which involves antagonism of various neurotransmitter receptors, including dopamine D4 and serotonin 5-HT2A receptors, contributing to its efficacy in alleviating psychotic symptoms. Clozapine is characterized by its relatively low propensity to cause extrapyramidal side effects compared to typical antipsychotics, making it a valuable option for treatment-resistant cases. However, it is associated with a risk of agranulocytosis, a potentially severe decrease in white blood cell count, necessitating regular blood monitoring. The substance is typically administered orally and has a complex pharmacokinetic profile, with a long half-life and extensive metabolism primarily in the liver. Clozapine's chemical structure includes a dibenzodiazepine core, which is integral to its pharmacological properties. Overall, while effective, its use requires careful management due to the associated risks and side effects.

Formula: C₁₈H₁₉ClN₄

InChI: InChI=1/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key: InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N

SMILES: CN1CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1

Synonyms:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
• 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
• 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• Apo-Clozapine
• Asaleptin
• Azaleptin
• Azaleptine
• Brn 0764984
• Ccris 9171
• Clorazil
• Cloril
• Clozapex
• Clozapin
• Clozapina
• Clozapina [INN-Spanish]
• Clozapinum
• Clozapinum [INN-Latin]
• Clozaril
• Fazaclo
• Fazaclo ODT
• Hf-1854
• Hsdb 6478
• Iprox
• Klozapol
• Leponex
• Lx 100-129
• Sizopin
• Unii-J60Ar2Ikic
• W-801
• Clozapine
• e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(
• CLOZAPINE ATYPICAL NEUROLEPTIC
• LIPONEX
• Lepotex
• COLZARIL
• 8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(e)(1,4)diazepine

Clozapine

Controlled Product

CAS: 5786-21-0

Applications An antipsychotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)

Formula: C₁₈H₁₉ClN₄

Color and Shape: Off-White

Molecular weight: 326.82

Ref: TR-C587500

Clozapine - Bio-X ™

Controlled Product

CAS: 5786-21-0

Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, 5-HT2A-C, 5-HT6, 5-HT7), alpha 1 and 2 adrenergic, histamine 1 and M1-M5 muscarinic receptors. In particular, its partial 5-HT1A agonist behaviour, its low affinity for the D2 Dopamine receptors and its antagonistic activity at 5-HT2A receptors, are properties, which make it useful as an antipsychotic drug. The FDA has approved Clozapine for use in the alleviation of symptoms in treatment-resistant schizophrenia patients, such as the risk of self-harm. Although not yet approved by the FDA, Clozapione exerts positive effects in Parkinson’s disease and bipolar disorder treatments. However, Clozapione is not currently a first line-therapy option, as it may cause agranulocytosis and other side effects such as orthostatic hypotension and hypersalivation.

Formula: C₁₈H₁₉ClN₄

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 326.82 g/mol

Ref: 3D-BC164328

Clozapine

Controlled Product

CAS: 5786-21-0

Partial 5-HT1A agonist; adrenergic, cholinergic, and histaminergic antagonist

Formula: C₁₈H₁₉ClN₄

Purity: Min. 97.5 Area-%

Color and Shape: Yellow Powder

Molecular weight: 326.82 g/mol

Ref: 3D-FC20526

Clozapine

CAS: 5786-21-0

Formula: C₁₈H₁₉ClN₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 326.83

Ref: 10-M01464

5-Acetyl-8-chloro-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one

CAS: 5786-21-0

Formula: C₁₅H₁₁ClN₂O₂

Color and Shape: Neat

Molecular weight: 286.713

Ref: TR-A603883