CAS 5790-69-2

2-Amino-5-chlorobenzenesulfonamide

Description:

2-Amino-5-chlorobenzenesulfonamide, with the CAS number 5790-69-2, is an organic compound characterized by the presence of an amino group (-NH2), a chlorobenzene moiety, and a sulfonamide group (-SO2NH2). This compound typically appears as a solid and is soluble in polar solvents due to its functional groups. It exhibits properties such as being a weak acid, which can participate in various chemical reactions, including nucleophilic substitutions and coupling reactions. The presence of the sulfonamide group imparts potential biological activity, making it of interest in medicinal chemistry, particularly in the development of antibacterial agents. Additionally, the chlorine atom on the benzene ring can influence the compound's reactivity and interaction with biological targets. Overall, 2-Amino-5-chlorobenzenesulfonamide serves as a versatile building block in organic synthesis and pharmaceutical applications, with its characteristics making it suitable for further functionalization and study in various chemical contexts.

Formula: C₆H₇ClN₂O₂S

InChI: InChI=1/C6H7ClN2O2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H,8H2,(H2,9,10,11)

SMILES: c1cc(c(cc1Cl)S(=O)(=O)N)N

Synonyms:

• Benzenesulfonamide, 2-Amino-5-Chloro-
• 2-Amino-5-chlorobenzenesulphonamide

2-Amino-5-chlorobenzenesulfonamide

CAS: 5790-69-2

Formula: C₆H₇ClN₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 206.6500

Ref: IN-DA00333N

2-Amino-5-chlorobenzenesulphonamide

CAS: 5790-69-2

2-Amino-5-chlorobenzenesulphonamide

Purity: 98%

Color and Shape: Powder

Molecular weight: 206.65g/mol

Ref: 54-OR2017

Hydrochlorothiazide Impurity 28

CAS: 5790-69-2

Formula: C₆H₇ClN₂O₂S

Molecular weight: 206.64

Ref: 4Z-H-0546

2-Amino-5-chlorobenzenesulfonamide

Controlled Product

CAS: 5790-69-2

Applications 2-Amino-5-chlorobenzenesulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).
References Cannazza, G., et. al.: Bioorg. Med. Chem. Lett., 19, 1254 (2009); Zivkovic, et al.: J. Pharmacol. Exp. Ther., 272, 300 (1995); Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999); Sun, Y., et al.: Nature, 417, 245 (2002); Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)

Formula: C₆H₇ClN₂O₂S

Color and Shape: Neat

Molecular weight: 206.65

Ref: TR-A603230

2-Amino-5-chlorobenzenesulfonamide

CAS: 5790-69-2

2-Amino-5-chlorobenzenesulfonamide is a synthetic chemical that is used in the manufacture of amides and diazoxide. It is also found naturally in humans as a metabolite of the amino acid histidine. 2-Amino-5-chlorobenzenesulfonamide has been shown to be a potent receptor for the modulation of acetylcholine release by binding to muscarinic receptors, including M1 and M2 subtypes, and inhibiting the enzyme hydrolysis of acetylcholine. This chemical has been shown to be chemically stable at pH 5 or higher, and it has been found to be resistant to hydrolysis by enzymes such as esterases, glucuronidases, glutathione reductase, and cytochrome P450. 2-Amino-5-chlorobenzenesulfonamide is also an enantiomer that can bind to collagen in the human

Formula: C₆H₇ClN₂O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 206.65 g/mol

Ref: 3D-FA151456

Hydrochlorothiazide Impurity 3

CAS: 5790-69-2

Formula: C₆H₇ClN₂O₂S

Molecular weight: 206.64

Ref: ST-EA-CP-H3015