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CAS 57944-13-5

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3'-deoxy-3'-fluorouridine

Description:
3'-Deoxy-3'-fluorouridine is a nucleoside analog of uridine, characterized by the substitution of a fluorine atom at the 3' position of the ribose sugar. This modification imparts unique properties to the molecule, making it of interest in medicinal chemistry, particularly in antiviral and anticancer research. The presence of the fluorine atom can enhance the stability of the nucleoside against enzymatic degradation, potentially improving its therapeutic efficacy. 3'-Deoxy-3'-fluorouridine is typically used in studies related to RNA synthesis inhibition and as a building block in the development of nucleotide analogs. Its structure allows it to interfere with nucleic acid metabolism, which can be exploited in the treatment of viral infections and certain types of cancer. Additionally, the compound is often evaluated for its pharmacokinetic properties and biological activity in various cellular models. As with many nucleoside analogs, understanding its mechanism of action and potential side effects is crucial for its application in clinical settings.
Formula:C9H11FN2O5
InChI:InChI=1/C9H11FN2O5/c10-6-4(3-13)17-8(7(6)15)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
SMILES:c1cn([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)F)O)c(=O)nc1O
Synonyms:
  • 1-(3-Deoxy-3-fluoro-.beta.-D-ribofuranosyl)uracil
  • 3'-F-3'-dU
  • 3'-fluoro-3'-desoxyuridine
  • CAINDEXNAME
  • Uridine, 3'-deoxy-3'-fluoro-
  • CAINDEXNAME:URIDINE,3'-DEOXY-3'-FLUORO USP/EP/BP
  • CAINDEXNAME:URIDINE,3'-DEOXY-3'-FLUORO
  • 3'-Fluoro-3'-deoxyuridine
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