CAS 58-14-0

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

Description:

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-, commonly known as Ethyl 5-(4-chlorophenyl)-2,4-pyrimidinediamine, is an organic compound characterized by its pyrimidine ring structure, which is a six-membered aromatic heterocycle containing two nitrogen atoms at the 2 and 4 positions. This compound features an ethyl group at the 6 position and a para-chlorophenyl group at the 5 position, contributing to its unique chemical properties. It is typically a solid at room temperature and may exhibit moderate solubility in polar solvents. The presence of amino groups in the structure allows for potential reactivity, including hydrogen bonding and nucleophilic substitution. This compound is of interest in various fields, including pharmaceuticals and agrochemicals, due to its potential biological activity. Safety data indicates that it should be handled with care, as it may pose health risks upon exposure. Proper storage and handling protocols are essential to ensure safety and stability.

Formula: C₁₂H₁₃ClN₄

InChI: InChI=1/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

InChI key: InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N

SMILES: C(C)C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2

Synonyms:

• 2, 4-Diamino-5-(4'-chlorophenyl)-6-ethylpyrimidine
• 2, 4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
• 2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine
• 4753 R.P.
• 5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
• 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
• 5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
• Bw 50-63
• Chloridin
• Chloridine
• Darachlor
• Darapram
• Daraprim
• Daraprime
• Diaminopyritamin
• Erbaprelina
• Khloridin
• Malacid
• Malocid
• Malocide
• Nsc 3061
• Pirimecidan
• Pirimetamin
• Pirimetamina
• Pyrimethamin
• Pyrimethamine
• Pyrimethamine Base
• Pyrimidine, 2,4-diamino-5-(p-chlorophenyl)-6-ethyl-
• Rp 4753
• Tindurin
• Tinduring
• Wr 2978
• 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
• 2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-
• 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diyldiamine
• 5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine
• 2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-
• 4753r.p.
• 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
• bw50-63

Pyrimethamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 248.71

Ref: 3B-P2037

Pyrimethamine

CAS: 58-14-0

Color and Shape: Neat

Ref: 61-FOR1630.00

PYRIMETHAMINE CRS

CAS: 58-14-0

PYRIMETHAMINE CRS

Formula: C₁₂H₁₃ClN₄

Color and Shape: Crystalline Powder. White. Colourless Crystals. Powder.

Molecular weight: 248.7114

Ref: 41-P4200000

PYRIMETHAMINE RS

CAS: 58-14-0

PYRIMETHAMINE RS

Formula: C₁₂H₁₃ClN₄

Molecular weight: 248.7114

Ref: 41-ICRS47051

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Formula: C₁₂H₁₃CIN₄

Purity: 99.5%

Color and Shape: White

Molecular weight: 352.01849

Ref: 47-1227

Pyrimethamine

CAS: 58-14-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₁₂H₁₃ClN₄

Color and Shape: White Powder

Molecular weight: 248.08287

Ref: 45-1589007

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 248.7114

Ref: IN-DA00IKHO

Pyrimethamine

CAS: 58-14-0

Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.

Formula: C₁₂H₁₃ClN₄

Purity: 99.67%

Color and Shape: Crystals

Molecular weight: 248.71

Ref: TM-T0849

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Purity: ≥98%

Molecular weight: 248.71g/mol

Ref: 54-BUP14770

Pyrimethamine

CAS: 58-14-0

Pyrimethamine

Purity: 98%

Molecular weight: 248.71g/mol

Ref: 54-OR1029094

Pyrimethamine-d3-15N3

CAS: 58-14-0

Formula: N₃C₁₂H₁₀D₃ClN

Color and Shape: Off-White Solid

Molecular weight: 254.71

Ref: 4Z-P-154004

Pyrimethamine

Controlled Product

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Color and Shape: Neat

Molecular weight: 248.71

Ref: 86-MM1630.00

Pyrimethamine

Controlled Product

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Color and Shape: Neat

Molecular weight: 248.71

Ref: 04-C16658000

Pyrimethamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Molecular weight: 248.72

Ref: 4Z-P-154001

Pyrimethamine-d5

CAS: 58-14-0

Formula: C₁₂H₈D₅ClN₄

Molecular weight: 253.74

Ref: 4Z-P-154003

Pyrimethamine

Controlled Product

CAS: 58-14-0

Applications Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.
References Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),

Formula: C₁₂H₁₃ClN₄

Color and Shape: White To Off-White

Molecular weight: 248.71

Ref: TR-P997240

Pyrimethamine

CAS: 58-14-0

Pyrimethamine is an antimalarial agent that has been used in the treatment of various infectious diseases. Pyrimethamine is a folic acid antagonist which inhibits the synthesis of DNA and RNA by inhibiting the enzyme dihydrofolate reductase. The drug binds to sulfadiazine, a sulfa drug, which prevents its conversion to active form and thereby prevents bacterial growth. Pyrimethamine can be administered orally or intravenously. It exhibits low toxicity and is excreted in the urine as an inactive metabolite. In vitro assays have shown pyrimethamine to be effective against HIV-1 infection, but it is not active against other viruses such as herpes simplex virus and influenza virus.

Formula: C₁₂H₁₃ClN₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 248.71 g/mol

Ref: 3D-FP27346

5-(4-Chlorophenyl)-6-ethylpyrimidine-2,4-diamine

CAS: 58-14-0

Formula: C₁₂H₁₃ClN₄

Purity: 95%

Color and Shape: No data available.

Molecular weight: 248.71

Ref: 10-F211965