CAS 58-55-9

Theophylline

Description:

Theophylline is a naturally occurring methylxanthine compound, primarily found in tea leaves and cocoa. It is classified as a bronchodilator, which means it helps to relax and open the airways in the lungs, making it useful in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). The chemical formula of theophylline is C7H8N4O2, and it has a molecular weight of approximately 180.17 g/mol. Theophylline exhibits a moderate solubility in water and is more soluble in organic solvents. Its structure features a purine-like ring system, which contributes to its biological activity. Theophylline acts by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic AMP, which promotes relaxation of bronchial smooth muscle. Additionally, it has anti-inflammatory properties and can enhance respiratory muscle function. While generally well-tolerated, theophylline can have side effects, particularly at higher doses, including gastrointestinal disturbances, insomnia, and increased heart rate. Its therapeutic use requires careful monitoring of blood levels due to its narrow therapeutic index.

Formula: C₇H₈N₄O₂

InChI: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

InChI key: InChIKey=ZFXYFBGIUFBOJW-UHFFFAOYSA-N

SMILES: O=C1C2=C(N(C)C(=O)N1C)N=CN2

Synonyms:

• 1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione
• 1,3-Dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• 1,3-Dimethyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione
• 1,3-Dimethyl-3,7-dihydro-purine-2,6-dione
• 1,3-Dimethylxanthine
• 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
• 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
• 3,9-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
• Accurbron
• Aerobin
• Aerolate
• Afonilm
• Apnecut
• Armophylline
• Asmax
• Austyn
• Bilordyl
• Brochoretard
• Bronkodyl
• Cetraphylline
• Chronophyllin
• Diffumal
• Dimethylxanthine
• Duraphyl
• Duraphyllin
• Egifilin
• Elan
• Elixophyllin
• Elixophylline
• Etheophyl
• Euphylong
• Insanovin
• LaBID
• Lanophyllin
• Lasma
• Liquophylline
• Nuelin
• Optiphyllin
• Parkophyllin
• Phylobid
• Physpan
• Pro-Vent
• Pseudotheophylline
• PulmiDur
• Pulmo-Timelets
• Respbid
• Respicur
• Slo-Bid
• Slo-Phyllin
• Solosin
• Sustaire
• Talotren
• Telb-DS
• Telbans
• Teofilina
• Teonova
• Teotard
• Tesona
• Theo-DS
• Theo-Dur
• Theo-Nite
• Theo-Sav
• Theobid
• Theochron
• Theoclear
• Theodel
• Theodrip
• Theofol
• Theograd
• Theolair
• Theon
• Theopek
• Theophyl
• Theophyllin
• Theoplus
• Theostat
• Theotard
• Theovent
• Throphylline
• Unifyl
• Unilong
• Uniphyl
• Uniphyllin
• Xanthium
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
• 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-

Aminophylline

CAS: 317-34-0, 58-55-9

Formula: C₁₄H₁₆N₈O₄·C₂H₈N₂

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 420.43

Ref: 3B-A2805

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 180.17

Ref: 3B-T0179

Theophylline

CAS: 58-55-9

Theophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates spermatogenesis and epididymal sperm quality. Theophylline has also been used as an internal standard for the measurement of plasma paracetamol levels in humans. This Thermo Scie

Formula: C₇H₈N₄O₂

Color and Shape: White to off-white, Powder

Molecular weight: 180.17

Ref: 02-J60203

Theophylline, 1mg/ml in Methanol

Controlled Product

CAS: 58-55-9

Color and Shape: Single Solution

Ref: LP-TPY-133-FB-1LM

Theophylline

CAS: 58-55-9

Color and Shape: Neat

Ref: LP-TPY-133-FB-10

Theophylline

Controlled Product

CAS: 58-55-9

Color and Shape: Neat

Ref: 61-FOR0176.00

THEOPHYLLINE CRS

CAS: 58-55-9

THEOPHYLLINE CRS

Ref: 41-T0800000

Theophylline

CAS: 58-55-9

Theophylline

Formula: C₇H₈N₄O₂

Purity: 99.9%

Color and Shape: White Solid

Molecular weight: 180.06473

Ref: 47-327

Theophylline

CAS: 58-55-9

Theophylline and aminophylline (excluding fenetylline) and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₇H₈N₄O₂

Color and Shape: White Powder

Molecular weight: 180.17 g/mol

Ref: 45-1653004

Theophylline Melting Point Standard (Approximately 271 degrees)

CAS: 58-55-9

Theophylline and aminophylline (excluding fenetylline) and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₇H₈N₄O₂

Color and Shape: White Crystalline Powder

Molecular weight: 180.06473

Ref: 45-1653117

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 180.1640

Ref: IN-DA00IABC

Theophylline

CAS: 58-55-9

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central

Formula: C₇H₈N₄O₂

Purity: 99.65% - 99.98%

Color and Shape: White Solid Powder

Molecular weight: 180.16

Ref: TM-T1083

Theophylline (Dimenhydrinate EP Impurity A, Diprophylline EP Impurity B)

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Color and Shape: White To Off-White Solid

Molecular weight: 180.17

Ref: 4Z-T-605

Theophylline

CAS: 58-55-9

Theophylline

Purity: ≥98%

Molecular weight: 180.16g/mol

Ref: 54-BUP18605

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: ≥ 99.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 180.16

Ref: 7W-GP6302

Theophylline

Controlled Product

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Color and Shape: Neat

Molecular weight: 180.16

Ref: 86-MM0176.00

Theophylline

Controlled Product

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Color and Shape: Neat

Molecular weight: 180.16

Ref: 04-C17446000

Theophylline 100 µg/mL in Acetonitrile

Controlled Product

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Color and Shape: Single Solution

Molecular weight: 180.16

Ref: 04-A17446000AL-100

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: 95%~99%

Molecular weight: 180.167

Ref: BP-BP1390

Theophylline 1.0 mg/ml in Methanol

Controlled Product

CAS: 58-55-9

Color and Shape: Single Solution

Ref: 61-AMP0176.00-01

Theophylline

CAS: 58-55-9

Theophylline

Formula: C₇H₈N₄O₂

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 180.17

Ref: 5G-82668

Caffeine EP Impurity A

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Molecular weight: 180.16

Ref: ST-EA-CP-C47001

Theophylline

Controlled Product

CAS: 58-55-9

Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975); Svedmyr, K., et al.: Allergy, 37, 111 (1982);

Formula: C₇H₈N₄O₂

Color and Shape: Off-White

Molecular weight: 180.16

Ref: TR-T343850

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 180.167

Ref: 10-F095062

1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine

Controlled Product

CAS: 58-55-9

1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine (1,3DMP) is a drug that has been used experimentally as a congestive heart failure treatment. It is an analogue of theophylline and has been shown to have similar effects on the cardiovascular system. 1,3DMP can be metabolized by cytochrome P450 enzymes to form compounds that are active in the nucleus of cells and may affect gene expression. The drug has also been shown to have a protective effect on the bowel when administered with anhydrous sodium sulphate. 1,3DMP binds to DNA in the nucleus of cells and inhibits nuclear dna synthesis by competitive inhibition with the natural substrate S-adenosylmethionine. This binding prevents transcription of DNA into RNA and protein synthesis. 1,3DMP also binds to proteins in human serum and has pharmacological activities such as

Formula: C₇H₈N₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 180.16 g/mol

Ref: 3D-FT28196

Theophylline anhydrous pure, 99%

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: min. 99%

Color and Shape: White to off -white to light yellow, Crystalline powder

Molecular weight: 180.16

Ref: SR-56135