CAS 58-55-9

Theophylline

Description:

Theophylline is a naturally occurring methylxanthine compound, primarily found in tea leaves and cocoa. It is classified as a bronchodilator, which means it helps to relax and open the airways in the lungs, making it useful in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). The chemical formula of theophylline is C7H8N4O2, and it has a molecular weight of approximately 180.17 g/mol. Theophylline exhibits a moderate solubility in water and is more soluble in organic solvents. Its structure features a purine-like ring system, which contributes to its biological activity. Theophylline acts by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic AMP, which promotes relaxation of bronchial smooth muscle. Additionally, it has anti-inflammatory properties and can enhance respiratory muscle function. While generally well-tolerated, theophylline can have side effects, particularly at higher doses, including gastrointestinal disturbances, insomnia, and increased heart rate. Its therapeutic use requires careful monitoring of blood levels due to its narrow therapeutic index.

Formula: C₇H₈N₄O₂

InChI: InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

InChI key: InChIKey=ZFXYFBGIUFBOJW-UHFFFAOYSA-N

SMILES: O=C1C2=C(N(C)C(=O)N1C)N=CN2

Synonyms:

• 1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione
• 1,3-Dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• 1,3-Dimethyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione
• 1,3-Dimethyl-3,7-dihydro-purine-2,6-dione
• 1,3-Dimethylxanthine
• 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
• 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
• 3,9-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
• Accurbron
• Aerobin
• Aerolate
• Afonilm
• Apnecut
• Armophylline
• Asmax
• Austyn
• Bilordyl
• Brochoretard
• Bronkodyl
• Cetraphylline
• Chronophyllin
• Diffumal
• Dimethylxanthine
• Duraphyl
• Duraphyllin
• Egifilin
• Elan
• Elixophyllin
• Elixophylline
• Etheophyl
• Euphylong
• Insanovin
• LaBID
• Lanophyllin
• Lasma
• Liquophylline
• Nuelin
• Optiphyllin
• Parkophyllin
• Phylobid
• Physpan
• Pro-Vent
• Pseudotheophylline
• PulmiDur
• Pulmo-Timelets
• Respbid
• Respicur
• Slo-Bid
• Slo-Phyllin
• Solosin
• Sustaire
• Talotren
• Telb-DS
• Telbans
• Teofilina
• Teonova
• Teotard
• Tesona
• Theo-DS
• Theo-Dur
• Theo-Nite
• Theo-Sav
• Theobid
• Theochron
• Theoclear
• Theodel
• Theodrip
• Theofol
• Theograd
• Theolair
• Theon
• Theopek
• Theophyl
• Theophyllin
• Theoplus
• Theostat
• Theotard
• Theovent
• Throphylline
• Unifyl
• Unilong
• Uniphyl
• Uniphyllin
• Xanthium
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-
• 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-

Theophylline

CAS: 58-55-9

Theophylline

Formula: C₇H₈N₄O₂

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 180.17

Ref: 5G-82668

Caffeine EP Impurity A

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Molecular weight: 180.16

Ref: ST-EA-CP-C47001

Theophylline

Controlled Product

CAS: 58-55-9

Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975); Svedmyr, K., et al.: Allergy, 37, 111 (1982);

Formula: C₇H₈N₄O₂

Color and Shape: Off-White

Molecular weight: 180.16

Ref: TR-T343850

Theophylline

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 180.167

Ref: 10-F095062

1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine

Controlled Product

CAS: 58-55-9

1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine (1,3DMP) is a drug that has been used experimentally as a congestive heart failure treatment. It is an analogue of theophylline and has been shown to have similar effects on the cardiovascular system. 1,3DMP can be metabolized by cytochrome P450 enzymes to form compounds that are active in the nucleus of cells and may affect gene expression. The drug has also been shown to have a protective effect on the bowel when administered with anhydrous sodium sulphate. 1,3DMP binds to DNA in the nucleus of cells and inhibits nuclear dna synthesis by competitive inhibition with the natural substrate S-adenosylmethionine. This binding prevents transcription of DNA into RNA and protein synthesis. 1,3DMP also binds to proteins in human serum and has pharmacological activities such as

Formula: C₇H₈N₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 180.16 g/mol

Ref: 3D-FT28196

Theophylline anhydrous pure, 99%

CAS: 58-55-9

Formula: C₇H₈N₄O₂

Purity: min. 99%

Color and Shape: White to off -white to light yellow, Crystalline powder

Molecular weight: 180.16

Ref: SR-56135