CAS 58-58-2: Puromycin hydrochloride
Description:Puromycin hydrochloride is an antibiotic compound that is derived from the bacterium *Streptomyces alboniger*. It is primarily known for its role as a protein synthesis inhibitor, specifically targeting the ribosomal machinery of both prokaryotic and eukaryotic cells. The compound functions by mimicking the structure of aminoacyl-tRNA, leading to premature termination of polypeptide chains during translation. Puromycin hydrochloride is typically presented as a white to off-white crystalline powder, soluble in water and various organic solvents. Its molecular formula includes elements such as carbon, hydrogen, nitrogen, and oxygen, contributing to its biological activity. In laboratory settings, puromycin is widely used in molecular biology for selecting genetically modified cells, as it can effectively eliminate non-resistant cells. However, due to its potent effects, handling requires caution, and appropriate safety measures should be observed. Overall, puromycin hydrochloride serves as a valuable tool in research, particularly in studies related to gene expression and protein synthesis.
Formula:C22H29N7O5·2ClH
InChI:InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1
InChI key:InChIKey=MKSVFGKWZLUTTO-FZFAUISWSA-N
SMILES:Cl.O=C(NC1C(O)C(OC1CO)N2C=NC=3C2=NC=NC3N(C)C)C(N)CC4=CC=C(OC)C=C4
- Synonyms:
- Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, hydrochloride (1:2)
- Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, dihydrochloride, L-
- Adenosine, 3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, (S)-
- Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride
- CL 16,536