CAS 58-58-2

Puromycin hydrochloride

Description:

Puromycin hydrochloride is an antibiotic compound that is derived from the bacterium *Streptomyces alboniger*. It is primarily known for its role as a protein synthesis inhibitor, specifically targeting the ribosomal machinery of both prokaryotic and eukaryotic cells. The compound functions by mimicking the structure of aminoacyl-tRNA, leading to premature termination of polypeptide chains during translation. Puromycin hydrochloride is typically presented as a white to off-white crystalline powder, soluble in water and various organic solvents. Its molecular formula includes elements such as carbon, hydrogen, nitrogen, and oxygen, contributing to its biological activity. In laboratory settings, puromycin is widely used in molecular biology for selecting genetically modified cells, as it can effectively eliminate non-resistant cells. However, due to its potent effects, handling requires caution, and appropriate safety measures should be observed. Overall, puromycin hydrochloride serves as a valuable tool in research, particularly in studies related to gene expression and protein synthesis.

Formula: C₂₂H₂₉N₇O₅·2ClH

InChI: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1

InChI key: InChIKey=MKSVFGKWZLUTTO-FZFAUISWSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N(C)C)N=CN3)O[C@H](CO)[C@H]1NC([C@H](CC4=CC=C(OC)C=C4)N)=O.Cl

Synonyms:

• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, hydrochloride (1:2)
• Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, dihydrochloride, L-
• Adenosine, 3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, (S)-
• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride
• CL 16,536

Puromycin dihydrochloride, 98%

CAS: 58-58-2

Puromycin dihydrochloride, 58-58-2, also known as stylomycin hydrochloride, is an aminoglycoside antibiotic which acts by inhibiting protein synthesis. Learn more.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purity: 98%

Color and Shape: White to pale cream, Powder

Molecular weight: 544.43

Ref: 02-J61278

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

CAS: 58-58-2

Puromycin, 58-58-2, is an aminoglycoside antibiotic produced by Streptomyces alboniger which acts by inhibiting protein synthesis. Learn more at Thermo Fisher Scientific.

Formula: C₂₂H₂₉N₇O₅

Color and Shape: Clear colorless to pale cream, Liquid

Molecular weight: 471.52

Ref: 02-J67236

Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride

CAS: 58-58-2

Formula: C₂₂H₃₁Cl₂N₇O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 544.4314

Ref: IN-DA00IABE

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Formula: C₂₂H₂₉N₇O₅·2ClH

Purity: By hplc: 98.48% (Typical Value in Batch COA)

Color and Shape: off-white powder

Molecular weight: 544.43g/mol

Ref: 54-BIP3340

Puromycin dihydrochloride (animal free)

CAS: 58-58-2

Puromycin dihydrochloride (animal free)

Formula: C₂₂H₂₉N₇O₅·2ClH

Purity: By hplc: 99.07% (Typical Value in Batch COA)

Color and Shape: slightly pink powder

Molecular weight: 544.43g/mol

Ref: 54-BIP4033

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Purity: ≥98%

Molecular weight: 544.44g/mol

Ref: 54-BUP13663

Puromycin DiHCl

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Molecular weight: 471.52 2 36.46

Ref: 4Z-P-301001

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride, from Streptomyces alboniger, blocks protein synthesis, acting as an antineoplastic and antitrypanosomal agent.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purity: 98.65% - 99.89%

Color and Shape: Physical Description White Powder (Ntp 1992)

Molecular weight: 544.44

Ref: TM-T2219

Puromycin dihydrochloride

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 544.44

Ref: 7W-GA1940

Puromycin Dihydrochloride

Controlled Product

CAS: 58-58-2

Applications Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Formula: C₂₂H₂₉N₇O₅·xHCl

Color and Shape: Neat

Molecular weight: 507.97

Ref: TR-P840320

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin is active against both prokaryotic and eukaryotic cells. Puromycin resistance gene (pac) is a common choice for the selection of mammalian cells since its first application in 1988, especially for therapeutic proteins in mammalian cells where it was used to produce high levels of protein of interest. Puromycin can also be used as a selection marker for Archea.

Formula: C₂₂H₃₁Cl₂N₇O₅

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 544.44 g/mol

Ref: 3D-NP09203

Puromycin Dihydrochloride (PRM), 98%

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purity: min. 98%

Color and Shape: White to pale yellow, Powder

Molecular weight: 544.44

Ref: SR-93909

Puromycin Dihydrochloride (PRM) for cell culture, Endotoxin (BET) 10EU/mg

CAS: 58-58-2

Formula: C₂₂H₂₉N₇O₅·2HCl

Purity: min. 98%

Color and Shape: White to pale yellow, Powder

Molecular weight: 544.44

Ref: SR-82361

Puromycin dihydrochloride

CAS: 58-58-2

M02245 - Puromycin dihydrochloride

Formula: C₂₂H₃₁Cl₂N₇O₅

Purity: 98%

Color and Shape: Solid, Powder

Molecular weight: 544.43

Ref: 10-M02245

Puromycin-D3 Dihydrochloride

Controlled Product

CAS: 58-58-2

Applications Puromycin-D3 Dihydrochloride is a labelled analogue of Puromycin Dihydrochloride (P840320), an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Formula: C₂₂H₂₆D₃N₇O₅•2(HCl)

Color and Shape: Neat

Molecular weight: 547.45

Ref: TR-P840322