CAS 58-82-2
:Bradykinin
Description:
Bradykinin is a peptide that plays a crucial role in various physiological processes, particularly in inflammation and blood pressure regulation. It is composed of nine amino acids, making it a nonapeptide, and is classified as a kinin. Bradykinin is known for its potent vasodilatory effects, which contribute to increased blood flow and reduced blood pressure. It acts primarily through the B2 receptor, although it can also interact with the B1 receptor under certain pathological conditions. The substance is produced from kininogen by the action of the enzyme kallikrein. In addition to its role in vasodilation, bradykinin is involved in pain signaling and the inflammatory response, often contributing to the sensation of pain and swelling during tissue injury. Its rapid degradation by enzymes such as angiotensin-converting enzyme (ACE) limits its duration of action in the body. Due to its significant biological effects, bradykinin is of interest in various medical research areas, including cardiovascular health and pain management.
Formula:C50H73N15O11
InChI:InChI=1/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
SMILES:c1ccc(cc1)C[C@@H](C(=N[C@@H](CO)C(=O)N1CCC[C@H]1C(=N[C@@H](Cc1ccccc1)C(=N[C@@H](CCCNC(=N)N)C(=O)O)O)O)O)N=C(CN=C([C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)N)O)O
Synonyms:- H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
- N~5~-(diaminomethylidene)ornithylprolylprolylglycylphenylalanylserylprolylphenylalanyl-N~5~-(diaminomethylidene)ornithine
- N~5~-(diaminomethylidene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-N~5~-(diaminomethylidene)-L-ornithine
- 1: PN: JP2005049164 SEQID: 1 claimed protein
- 1: PN: US20040198666 SEQID: 1 unclaimed protein
- 1: PN: US20040220110 PAGE: 2 unclaimed protein
- 1: PN: WO02102835 SEQID: 3 unclaimed protein
- 1: PN: WO2006130718 SEQID: 1 unclaimed protein
- 1: PN: WO2006134125 SEQID: 22 claimed protein
- 1021: PN: WO2006091861 SEQID: 1021 claimed protein
- 107: PN: WO2006069765 SEQID: 107 claimed protein
- 11: PN: US20040209344 SEQID: 7 unclaimed protein
- 13: PN: WO0023092 SEQID: 13 unclaimed protein
- 14: PN: US6525021 SEQID: 13 unclaimed protein
- 147: PN: US20030119021 SEQID: 25 unclaimed protein
- 15: PN: US6258776 SEQID: 24 unclaimed protein
- 153: PN: WO2006067198 SEQID: 165 claimed protein
- 16: PN: WO2006079099 SEQID: 1 unclaimed protein
- 165: PN: US20050175581 SEQID: 165 unclaimed protein
- 175: PN: WO2008008805 SEQID: 178 unclaimed protein
- 18: PN: JP2006280210 SEQID: 18 unclaimed protein
- 187: PN: US20030176421 PAGE: 54-55 claimed protein
- 19: PN: US20060223140 SEQID: 18 claimed protein
- 19: PN: WO2007022248 SEQID: 19 claimed protein
- 2: PN: WO2005042027 SEQID: 1 unclaimed protein
- 2: PN: WO2005057221 PAGE: 17 unclaimed protein
- 3: PN: WO02059343 SEQID: 3 unclaimed protein
- 3: PN: WO2006050091 SEQID: 7 claimed protein
- 38: PN: WO2006017688 SEQID: 38 unclaimed protein
- 41: PN: WO03028666 SEQID: 38 unclaimed protein
- 57: PN: FR2862981 SEQID: 57 unclaimed protein
- 57: PN: WO2004033476 SEQID: 57 unclaimed protein
- 6: PN: US6395513 SEQID: 9 unclaimed protein
- 6: PN: WO0112656 SEQID: 47 unclaimed protein
- 7: PN: US20040170685 SEQID: 7 unclaimed protein
- 8: PN: WO2004069857 PAGE: 49 unclaimed protein
- 9: PN: US20060013855 SEQID: 9 unclaimed protein
- 9: PN: WO2004068928 PAGE: 65 unclaimed protein
- 9: PN: WO2005097186 SEQID: 9 claimed protein
- Arginine, N2-[N-[1-[N-[N-[N-[1-(1-arginyl-L-prolyl)-L-prolyl]glycyl]-3-phenylalanyl]seryl]prolyl]-3-phenylalanyl]-
- Bradiquinina
- Bradykinin (human)
- Bradykinine
- Brs 640
- Callidin I
- Kallidin 9
- Kallidin I
- L-Arginine, L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-
- L-Bradykinin
- See more synonyms
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Found 9 products.
Bradykinin
CAS:<p>For cellular and molecular biology applications</p>Color and Shape:White to off-white, SolidBradykinin
CAS:<p>Bradykinin is an inflammatory mediator.</p>Formula:C50H73N15O11Purity:99.68%Color and Shape:SolidMolecular weight:1060.212-[[2-[[1-[2-[[2-[[2-[[1-[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl ]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethy
CAS:<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>Formula:C50H73N15O11Molecular weight:1,060.22 g/molBradykinin Trifluoroacetic Acid
CAS:Controlled ProductFormula:C50H73N15O11•xC2HO2F3Color and Shape:NeatBradykinin (Human, Bovine, Rat, Mouse)
CAS:<p>Bradykinin is a peptide hormone that is produced in the body by the kininase enzyme. It is an activator of ion channels and ligand for the G-protein coupled receptors B1, B2, and B3. Bradykinin is used as a research tool to study cell biology, pharmacology, and life science. It interacts with proteins such as erythrocyte protein band 4.4, alpha-2-macroglobulin receptor, alpha-bungarotoxin binding protein, beta-chain integrin receptor, and platelet membrane glycoprotein IIb/IIIa receptor. Bradykinin has been shown to inhibit the activity of bradykinin B1 receptor (Ki = 0.4 nM) and bradykinin B2 receptor (Ki = 0.6 nM).</p>Formula:C50H73N15O11Purity:Min. 95%Molecular weight:1,060.2 g/molBradykinin
CAS:<p>Custom research peptide; min purity 95%.</p>Formula:C50H73N15O11Purity:Min. 95%Molecular weight:1,060.22 g/molBradykinin
CAS:<p>Bradykinin is a peptide that belongs to the class of natural compounds. It is a signal peptide, which is used in the regulation of various biological functions such as inflammation and pain. Bradykinin has been shown to have an anti-cancer effect on cancer tissues, with the highest potency observed in bone cancer. Bradykinin also causes an increase in eosinophil cationic protein, which can be measured in biological samples such as blood. This compound has been shown to have a variety of effects on enzyme activities and can be used as a chemotherapeutic agent for diseases such as congestive heart failure and chronic kidney disease. Bradykinin has low potency for inhibition of creatinine sulfate synthesis.</p>Formula:C50H73N15O11Purity:Min. 95%Molecular weight:1,060.22 g/mol
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