CAS 581-05-5

alpha-melanocyte stimulating hormone

Description:

Alpha-melanocyte-stimulating hormone (α-MSH) is a peptide hormone that plays a crucial role in regulating various physiological processes, including pigmentation, appetite, and energy homeostasis. It is derived from the pro-opiomelanocortin (POMC) precursor and consists of a sequence of 13 amino acids. The primary function of α-MSH is to stimulate melanogenesis, the production of melanin in melanocytes, which affects skin and hair pigmentation. Additionally, α-MSH has been implicated in the modulation of inflammatory responses and the regulation of appetite, influencing body weight and metabolism. The substance is characterized by its ability to bind to melanocortin receptors, particularly MC1R, which mediates its effects on pigmentation. α-MSH is also involved in the central nervous system, where it can affect behavior and energy balance. Due to its diverse roles, α-MSH is of interest in research related to skin disorders, obesity, and metabolic diseases. Its CAS number, 581-05-5, is used for identification in chemical databases and regulatory contexts.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

InChI: InChI=1/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1

SMILES: CC(C)[C@@H](C(=N)O)N=C([C@@H]1CCCN1C(=O)[C@H](CCCCN)N=C(CN=C([C@H](Cc1c[nH]c2ccccc12)N=C([C@H](CCCNC(=N)N)N=C([C@H](Cc1ccccc1)N=C([C@H](Cc1cnc[nH]1)N=C([C@H](CCC(=O)O)N=C([C@H](CCSC)N=C([C@H](CO)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](CO)N=C(C)O)O)O)O)O)O)O)O)O)O)O)O

Synonyms:

• .alpha.-MSH
• Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
• N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
• melanotan,α-MSH,PT-141

α-Melanocyte Stimulating Hormone amide

CAS: 581-05-5

alpha-Melanocyte Stimulating Hormone amide; An endogenous melanocortin receptor agonist. Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-, IL-6 and NO and induces anti-inflammatory cytokine IL-10.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Molecular weight: 1664.88

Ref: 02-J64310

α-MSH

CAS: 581-05-5

α-Melanotropin, also known as α-melanocyte-stimulating hormone (α-MSH), is a 13-amino acid peptide originally characterized as a neuropeptide derived from the pituitary gland. α-MSH is synthesized from pro-opiomelanocortin (POMC) by the action of specific prohormone convertases and is involved in the regulation of important physiological functions including food intake, energy homeostasis, modulation of immune responses and photoprotection.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Purity: 98.2%

Color and Shape: White Lyophilisate

Molecular weight: 1664.91

Ref: 01-4008476

N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide

CAS: 581-05-5

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Purity: 99%

Color and Shape: Solid

Molecular weight: 1664.8837

Ref: IN-DA00E8UA

α-MSH

CAS: 581-05-5

α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Purity: 99.10% - 99.67%

Color and Shape: White Powder

Molecular weight: 1664.89

Ref: TM-T7813

a-MSH, amide

CAS: 581-05-5

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₁₈H₁₇₄N₃₄O₃₅S

Molecular weight: 1,664.91 g/mol

Ref: 3D-PP50839

α-MSH (Human, Porcine, Bovine, Rat, Mouse)

CAS: 581-05-5

Alpha-MSH is a peptide that binds to the Melanocortin 1 receptor. Alpha-MSH is a peptide hormone and neurotransmitter that is involved in the regulation of numerous physiological processes, including appetite, sexual desire, immune response, and skin pigmentation. In addition to its role as a natural hormone, it has been studied as a potential drug for the treatment of obesity and other diseases. The product can also be used as an antibody probe for Western blotting or immunohistochemistry.  The product is produced synthetically.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Purity: Min. 95%

Molecular weight: 1,664.9 g/mol

Ref: 3D-PMR-4057-V

α-MSH

CAS: 581-05-5

Custom research peptide; min purity 95%.

Formula: C₇₇H₁₀₉N₂₁O₁₉S

Purity: Min. 95%

Molecular weight: 1,664.9 g/mol

Ref: 3D-PM17126