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CAS 581-88-4

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Debrisoquine sulfate

Description:
Debrisoquine sulfate is a chemical compound primarily used as a pharmaceutical agent, particularly in the study of drug metabolism and pharmacogenetics. It is a selective inhibitor of the enzyme CYP2D6, which plays a crucial role in the metabolism of various drugs. The compound is typically presented as a white to off-white crystalline powder and is soluble in water, making it suitable for various formulations. Debrisoquine sulfate is known for its role in the debrisoquine/sparteine oxidation polymorphism, which highlights genetic variations in drug metabolism among individuals. This characteristic is significant in personalized medicine, as it helps predict patient responses to certain medications. The compound's pharmacological effects include antihypertensive properties, although its clinical use has diminished over time due to the development of newer agents. Safety and efficacy profiles are well-documented, and it is essential to consider potential drug interactions, especially in patients with varying CYP2D6 activity. Overall, Debrisoquine sulfate serves as an important tool in both clinical and research settings for understanding drug metabolism.
Formula:C10H13N3H2O4S
InChI:InChI=1S/C10H13N3.H2O4S/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;1-5(2,3)4/h1-4H,5-7H2,(H3,11,12);(H2,1,2,3,4)
InChI key:InChIKey=SVYNLIRHKQCPNE-UHFFFAOYSA-N
SMILES:S(=O)(=O)(O)O.C(=N)(N)N1CC=2C(CC1)=CC=CC2
Synonyms:
  • 1,2,3,4-Tetrahydro-isoquinoline-2-carboxamidine sulfate
  • 2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-, sulfate (2:1)
  • 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
  • 3,4-Dihydroisoquinoline-2(1H)-carboximidamide hemisulfate
  • 3,4-dihydroisoquinoline-2(1H)-carboximidamide sulfate (2:1)
  • Bis(2-Amidino-1,2,3,4-Tetrahydroisoquinoline) Sulphate
  • Debrisoquin hemisulfate
  • Debrisoquin sulfate
  • Debrisoquine Sulphate
  • Debrisoquine hemisulfate
  • See more synonyms
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