CAS 5817-39-0

3′,5′,3-Triiodothyronine

Description:

3′,5′,3-Triiodothyronine, commonly known as T3, is a thyroid hormone that plays a crucial role in regulating metabolism, growth, and development in the body. It is a derivative of thyroxine (T4) and is characterized by the presence of three iodine atoms attached to its aromatic rings, which significantly influences its biological activity. T3 is a small, lipophilic molecule that can easily cross cell membranes and bind to nuclear receptors, thereby modulating gene expression. Its synthesis occurs primarily in the thyroid gland, where it is produced from the conversion of T4 through the removal of one iodine atom. T3 is essential for maintaining metabolic homeostasis, influencing processes such as protein synthesis, carbohydrate metabolism, and lipid metabolism. Abnormal levels of T3 can lead to various health issues, including hyperthyroidism or hypothyroidism. The substance is typically administered in synthetic form for therapeutic purposes, particularly in cases of thyroid dysfunction. Its CAS number, 5817-39-0, is used for identification in chemical databases and regulatory contexts.

Formula: C₁₅H₁₂I₃NO₄

InChI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI key: InChIKey=HZCBWYNLGPIQRK-LBPRGKRZSA-N

SMILES: O(C1=C(I)C=C(C[C@@H](C(O)=O)N)C=C1)C2=CC(I)=C(O)C(I)=C2

Synonyms:

• (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid
• (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid
• (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoicacid
• 3,3',5'-triiodo-L-thyronine
• 3,3′,5′-<span class="text-smallcaps">L</span>-Triiodothyronine
• 3,3′,5′-T₃
• 3,3′,5′-Triiodo-<span class="text-smallcaps">L</span>-thyronine
• 3,3′,5′-Triiodothyronine
• 3′,5′,3-Triiodothyronine
• <span class="text-smallcaps">L</span>-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-
• Alanine, 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, <span class="text-smallcaps">L</span>-
• Isoliothyronine
• O-(4-Hydroxy-3,5-diiodophenyl)-3-iodo-<span class="text-smallcaps">L</span>-tyrosine
• Reverse <span class="text-smallcaps">L</span>-triiodothyronine
• Reverse T3
• Reverse T₃
• Reverse triiodothyronine
• rT₃
• L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-
• O-(4-Hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
• Alanine, 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, L-

3,3',5'-Triiodo-L-thyronine

CAS: 5817-39-0

Formula: C₁₅H₁₂I₃NO₄

Purity: 96%

Color and Shape: Solid

Molecular weight: 650.9735

Ref: IN-DA00370O

REVERSE T3

CAS: 5817-39-0

REVERSE T3

Purity: ≥95%

Molecular weight: 650.97g/mol

Ref: 54-BUP01904

3,3'',5''-Triiodo-L-thyronine

CAS: 5817-39-0

Formula: C₁₅H₁₂I₃NO₄

Purity: ≥ 95.0%

Color and Shape: White to beige or tan solid

Molecular weight: 650.97

Ref: 7W-GM7296

Levothyroxine EP Impurity K (3,3',5'-Triiodo-L-Thyronine)

CAS: 5817-39-0

Formula: C₁₅H₁₂I₃NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 650.98

Ref: 4Z-L-4628

(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic Acid (3,3',5'-Triiodo-L-Thyronine)

CAS: 5817-39-0

Color and Shape: Neat

Ref: 86-MM0694.10

REVERSE T3

CAS: 5817-39-0

Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.

Formula: C₁₅H₁₂I₃NO₄

Purity: 95.99% - 97.89%

Color and Shape: Powder

Molecular weight: 650.97

Ref: TM-T7578

3,3',5'-Triiodo-L-thyronine

CAS: 5817-39-0

Formula: C₁₅H₁₂I₃NO₄

Color and Shape: Light Beige To Grey

Molecular weight: 650.97

Ref: TR-T795350

3,3',5'-Triiodo-L-thyronine

CAS: 5817-39-0

Triiodothyronine is a thyroid hormone that is used for oral hypoglycaemic therapy in patients with diabetes mellitus. It has been shown to be effective in the treatment of congestive heart failure and experimental models of cardiac hypertrophy. Triiodothyronine has also been shown to have strong pharmacological effects on voltage-dependent calcium channels and integrin receptors. The clinical use of triiodothyronine is limited by its toxicity, which may be caused by its interference with the production of thyroxine or triiodothyronine, as well as its ability to alter the level of iodide in the blood.

Formula: C₁₅H₁₂I₃NO₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 650.97 g/mol

Ref: 3D-FT28505

Levothyroxine EP Impurity K

CAS: 5817-39-0

Formula: C₁₅H₁₂I₃NO₄

Molecular weight: 650.9

Ref: ST-EA-CP-L18011