Z-Asp(ONp)-OBzl, also known as Z-Aspartic acid (p-nitrophenyl ester) benzyl ester, is a chemical compound characterized by its structure, which includes a protected aspartic acid moiety. The "Z" denotes the benzyloxycarbonyl (Cbz) protecting group, which is commonly used to protect amino groups during peptide synthesis. The "ONp" refers to the p-nitrophenyl ester, which is a good leaving group, making it useful in various chemical reactions, particularly in peptide coupling. The "OBzl" indicates the presence of a benzyl ester, which provides additional stability and solubility. This compound is typically utilized in organic synthesis and peptide chemistry, serving as an intermediate in the preparation of peptides and other bioactive molecules. Its properties include moderate solubility in organic solvents and stability under standard laboratory conditions, although it may be sensitive to moisture and light. Overall, Z-Asp(ONp)-OBzl is a valuable building block in the synthesis of more complex organic compounds.

Z-Asp(ONp)-OBzl

58238-28-1: Z-Asp(ONp)-OBzl, also known as Z-Aspartic acid (p-nitrophenyl ester) benzyl ester, is a chemical compound characterized by its structure, which includes a protected aspartic acid moiety. The "Z" denotes the benzyloxycarbonyl (Cbz) protecting group, which is commonly used to protect amino groups during peptide synthesis. The "ONp" refers to the p-nitrophenyl ester, which is a good leaving group, making it useful in various chemical reactions, particularly in peptide coupling. The "OBzl" indicates the presence of a benzyl ester, which provides additional stability and solubility. This compound is typically utilized in organic synthesis and peptide chemistry, serving as an intermediate in the preparation of peptides and other bioactive molecules. Its properties include moderate solubility in organic solvents and stability under standard laboratory conditions, although it may be sensitive to moisture and light. Overall, Z-Asp(ONp)-OBzl is a valuable building block in the synthesis of more complex organic compounds.

<p>Z-Asp(ONp)-OBzl is a synthetic compound with minimal side-chain that can be used as a condensation and deprotection reagent in the synthesis of peptides. It functions to selectively cleave the N-terminal amino group from an unprotected peptide. This side chain is not present on natural amino acids and therefore provides selectivity for the N-terminal amino acid. Z-Asp(ONp)-OBzl has been found to be a more controllable and selective alternative to other deprotection reagents such as DBU, DCC, or TFA. The use of this reagent in peptide synthesis has been shown to provide high yields of unblocked chains with minimal side reactions.</p>

CAS 58238-28-1

Z-Asp(ONp)-OBzl

Z-Asp(ONp)-OBzl

Ref: 3D-FA111452