CAS 583840-03-3

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 1-oxide

Description:

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 1-oxide, with CAS number 583840-03-3, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amides, phenoxy, and a pyridine moiety. This compound features a chloro and trifluoromethyl substituent on the aromatic ring, contributing to its unique chemical properties, including potential lipophilicity and reactivity. The presence of the N-methyl group and the carboxamide functionality suggests that it may exhibit hydrogen bonding capabilities, influencing its solubility and interaction with biological targets. As a result, this compound may be of interest in pharmaceutical research, particularly in the development of therapeutic agents. Its stability, solubility, and reactivity can be influenced by environmental factors such as pH and temperature. Overall, the compound's intricate structure and functional groups make it a subject of interest in medicinal chemistry and material science.

Formula: C₂₁H₁₆ClF₃N₄O₄

InChI: InChI=1/C21H16ClF3N4O4/c1-26-19(30)18-11-15(8-9-29(18)32)33-14-5-2-12(3-6-14)27-20(31)28-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,27,28,31)

SMILES: CNC(=O)c1cc(ccn1=O)Oc1ccc(cc1)NC(=Nc1ccc(c(c1)C(F)(F)F)Cl)O

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide

CAS: 583840-03-3

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcarbamoyl)pyridine 1-oxide

Purity: 97%

Molecular weight: 480.83g/mol

Ref: 54-PC1006772

Sorafenib N-oxide

CAS: 583840-03-3

Sorafenib N-oxide, active sorafenib metabolite, inhibits FLT3-ITD (Kd=70 nM), targets AML, selectivity for FLT3-ITD+, also mixes CYP3A4 inhibitor (Ki=15 μM).

Formula: C₂₁H₁₆ClF₃N₄O₄

Color and Shape: Solid

Molecular weight: 480.83

Ref: TM-T36681

Sorafenib N-Oxide

CAS: 583840-03-3

Formula: C₂₁H₁₆ClF₃N₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 480.83

Ref: 4Z-S-273

Sorafenib N-oxide

CAS: 583840-03-3

Sorafenib N-oxide is a potent anti-angiogenic agent that inhibits the growth and proliferation of new blood vessels. It has been shown to inhibit the production of epidermal growth factor, which plays an important role in the formation of new blood vessels. Sorafenib N-oxide also induces apoptosis in cancer cells by inhibiting cell factor and stem cell factor, which are necessary for cell survival. This drug has been shown to be effective against metastatic colorectal cancer in animal models, as well as renal cell cancer in humans. Sorafenib N-oxide also causes mitochondrial membrane depolarization, leading to cell death. In addition, this drug has antiangiogenic properties and inhibits the Mcl-1 protein.

Formula: C₂₁H₁₆ClF₃N₄O₄

Purity: Min. 95%

Color and Shape: Beige Powder

Molecular weight: 480.82 g/mol

Ref: 3D-FS27857

Sorafenib N-Oxide

Controlled Product

CAS: 583840-03-3

Formula: C₂₁H₁₆ClF₃N₄O₄

Color and Shape: Beige

Molecular weight: 480.82

Ref: TR-S676870

Sorafenib N-Oxide

CAS: 583840-03-3

Formula: C₂₁H₁₆ClF₃N₄O₄

Molecular weight: 480.83

Ref: ST-EA-CP-S16012