CAS 58479-68-8

Platycodin D

Description:

Platycodin D is a triterpenoid saponin primarily derived from the root of Platycodon grandiflorus, a plant commonly used in traditional medicine, particularly in East Asia. It is known for its various biological activities, including anti-inflammatory, immunomodulatory, and anticancer properties. The chemical structure of Platycodin D features a dammarane-type skeleton, which contributes to its bioactivity. It is typically characterized by its solubility in water and organic solvents, although its solubility can vary depending on the solvent used. Platycodin D has been the subject of numerous studies investigating its pharmacological effects, including its potential to enhance respiratory health and its role in modulating immune responses. Additionally, it exhibits cytotoxic effects against certain cancer cell lines, making it a compound of interest in cancer research. As with many natural products, the extraction and purification processes can influence its efficacy and bioavailability, highlighting the importance of proper analytical techniques in studying its properties and applications.

Formula: C₅₇H₉₂O₂₈

InChI: InChI=1S/C57H92O28/c1-23-40(81-45-39(72)41(28(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)27(63)17-77-48(42)85-50(74)57-12-11-51(2,3)13-25(57)24-7-8-30-52(4)14-26(62)44(84-47-37(70)35(68)34(67)29(16-58)80-47)55(19-59,20-60)31(52)9-10-53(30,5)54(24,6)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25-,26-,27-,28+,29+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48-,49-,52+,53+,54+,56+,57+/m0/s1

InChI key: InChIKey=CYBWUNOAQPMRBA-NDTOZIJESA-N

SMILES: C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@@H](O[C@H]4[C@H](O)[C@](CO)(O)CO4)[C@H](O)CO3)[C@H](C)O2)[C@@H](O)[C@@H](O)CO1)(=O)[C@]56[C@](C=7[C@@](C)(C[C@H]5O)[C@@]8(C)[C@](CC7)([C@]9(C)[C@@](CC8)(C(CO)(CO)[C@@H](O[C@@H]%10O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%10O)[C@@H](O)C9)[H])[H])(CC(C)(C)CC6)[H]

Synonyms:

• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• 3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl]-beta-D-xylopyranosyl-(1->4)-6-deoxy-alpha-L-mannopyranosyl-(1->2)-1-O-[(2beta,3beta,16alpha)-3-(beta-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-28-oxoolean-12-en-28-yl]-alpha-L-arabinopyranose
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• Olean-12-en-28-oic acid, 3-(β-<span class="text-smallcaps">D</smallcap>-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-<smallcap>D</smallcap>-apio-β-<smallcap>D</smallcap>-furanosyl-(1→3)-O-β-<smallcap>D</smallcap>-xylopyranosyl-(1→4)-O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-α-<smallcap>L</span>-arabinopyranosyl ester, (2β,3β,16α)-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• beta-D-xylopyranosyl-(1-4)-O-6-deoxy-alpha-L-mannopyranosyl-
• (1-2)-L-arabinopyranosyl ester, (2beta,3beta,16alpha)-
• Olean-12-en-28-oic acid, 3-(beta-D-glucopyranosyloxy)-
• 2,16,23,24-tetrahydroxy-, O-D-apio-beta-D-furanosyl-(1-3)-O-
• Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,16α)-

PLATYCODIN D CRS

CAS: 58479-68-8

PLATYCODIN D CRS

Ref: 41-Y0001946

Platycodin D

CAS: 58479-68-8

Formula: C₅₇H₉₂O₂₈

Purity: 95%

Color and Shape: Solid

Molecular weight: 1225.3236

Ref: IN-DA00EBH4

Platycodin D

CAS: 58479-68-8

Formula: C₅₇H₉₂O₂₈

Molecular weight: 1225.34

Ref: 7W-GY7597

Platycodin D

CAS: 58479-68-8

Platycodon D (PD) and D3 (PD3) isolated from Platycodon grandiflorum has been previously reported to show anti-inflammatory activities in rats, PD may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, suggest a dichotomous regulation of these important proinflammatory mediators by PD and PD3.

Formula: C₅₇H₉₂O₂₈

Purity: 95%~99%

Color and Shape: White powder

Molecular weight: 1225.34

Ref: BP-BP1111

Platycodin D

CAS: 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.

Formula: C₅₇H₉₂O₂₈

Purity: 99.2% - 99.65%

Color and Shape: Solid

Molecular weight: 1225.32

Ref: TM-T3889

Platycodin d

CAS: 58479-68-8

Natural glycoside

Formula: C₅₇H₉₂O₂₈

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 1225.34

Ref: 5G-80518

Platycodin D

Controlled Product

CAS: 58479-68-8

Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.
References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);

Formula: C₅₇H₉₂O₂₈

Color and Shape: Neat

Molecular weight: 1225.32

Ref: TR-P578200

Platycodin D

CAS: 58479-68-8

Platycodin D is a natural product that belongs to the class of platycodins. It is a polysaccharide with anti-inflammatory properties and has been shown to suppress inflammation, oxidative injury, and improve mitochondrial function in vitro. Platycodin D also inhibits Toll-like receptor (TLR) signaling pathways that are activated by extracellular bacteria or their products. Platycodin D binds to dsDNA and inhibits DNA binding proteins such as dextran sulfate. This interaction prevents the induction of the inflammatory response. The effects of platycodin D have been demonstrated in an experimental model involving mice. In vivo studies on rats have shown that this compound has an anti-inflammatory effect and reduces oxidative injury.

Formula: C₅₇H₉₂O₂₈

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 1,225.32 g/mol

Ref: 3D-FP73789