CAS 5852-78-8

5-Carboxy-8-hydroxyquinoline

Description:

5-Carboxy-8-hydroxyquinoline, with the CAS number 5852-78-8, is an organic compound that belongs to the class of quinoline derivatives. It features a hydroxyl group (-OH) and a carboxylic acid group (-COOH) attached to the quinoline ring, which contributes to its chemical reactivity and solubility in polar solvents. This compound is known for its chelating properties, allowing it to form stable complexes with metal ions, making it useful in various applications, including analytical chemistry and biochemistry. The presence of both the hydroxyl and carboxylic acid functional groups enhances its ability to participate in hydrogen bonding, influencing its solubility and interaction with biological systems. Additionally, 5-Carboxy-8-hydroxyquinoline exhibits fluorescence, which can be exploited in sensing applications. Its structural characteristics and functional groups make it a valuable compound in research, particularly in studies involving metal ion detection and coordination chemistry.

Formula: C₁₀H₇NO₃

5-​Quinolinecarboxylic acid, 8-​hydroxy-

CAS: 5852-78-8

Formula: C₁₀H₇NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 189.1675

Ref: IN-DA003NII

IOX1

CAS: 5852-78-8

IOX1

Purity: ≥98%

Molecular weight: 189.17g/mol

Ref: 54-BUP05967

5-Carboxy-8-hydroxyquinoline

CAS: 5852-78-8

Formula: C₁₀H₇NO₃

Purity: ≥ 95.0%

Color and Shape: White to yellow powder

Molecular weight: 189.17

Ref: 7W-GL4331

IOX1

CAS: 5852-78-8

IOX1, a broad-spectrum 2OG oxygenase inhibitor, IC50: KDM4A - 0.6uM, KDM3A - 0.1uM.

Formula: C₁₀H₇NO₃

Purity: 99.67%

Color and Shape: Solid

Molecular weight: 189.17

Ref: TM-T6545

8-Hydroxyquinoline-5-carboxylic acid

CAS: 5852-78-8

8-Hydroxyquinoline-5-carboxylic acid

Formula: C₁₀H₇NO₃

Purity: 95%

Color and Shape: brown powder

Molecular weight: 189.17g/mol

Ref: 54-OR52383

8-HYDROXYQUINOLINE-5-CARBOXYLIC ACID

CAS: 5852-78-8

Formula: C₁₀H₇NO₃

Purity: 97%

Molecular weight: 189.17

Ref: 10-F499950

8-Hydroxyquinoline-5-carboxylic Acid

Controlled Product

CAS: 5852-78-8

Applications 8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
References Rose, N.R., et al.: J. Med. Chem., 55, 6639 (2012); Flashman, E., et al.: J. Biol. Chem., 283, 3808 (2007);

Formula: C₁₀H₇NO₃

Color and Shape: Neat

Molecular weight: 189.167

Ref: TR-H953415

JMJD2 Inhibitor, 5-carboxy-8HQ

CAS: 5852-78-8

JMJD2 is an enzyme that catalyzes the methylation of histone H3 at lysine 27. JMJD2 inhibitors are compounds that inhibit JMJD2 activity, which may be used to treat cancer. This class of drugs inhibits the activity of JMJD2 by binding to the active site and blocking the substrate from entering. The most potent compound in this class, 5-carboxy-8HQ, has been shown to have antibacterial efficacy in a squamous cell carcinoma model system and up-regulated expression in wild-type cells. Additionally, this compound has been shown to significantly inhibit tumor growth in a mouse model of atherosclerotic lesion.

Formula: C₁₀H₇NO₃

Purity: Min. 95%

Molecular weight: 189.17 g/mol

Ref: 3D-FAA85278