CAS 58569-55-4

(5-methionine)enkephalin

Description:

(5-Methionine)enkephalin, also known as Met-enkephalin, is a pentapeptide that plays a significant role in the body's pain modulation and stress response. It is composed of five amino acids, specifically tyrosine, glycine, phenylalanine, leucine, and methionine, with methionine being the fifth amino acid at the C-terminus. This peptide is an endogenous opioid, meaning it is naturally produced in the body and binds to opioid receptors, particularly the delta-opioid receptor, to exert analgesic effects. Met-enkephalin is involved in various physiological processes, including pain relief, mood regulation, and the modulation of immune responses. It is soluble in water and exhibits stability under physiological conditions, although it can be susceptible to enzymatic degradation. The CAS number 58569-55-4 uniquely identifies this compound in chemical databases, facilitating research and application in pharmacology and biochemistry. Its study has implications for developing pain management therapies and understanding the mechanisms of addiction and mood disorders.

Formula: C₂₇H₃₅N₅O₇S

InChI: InChI=1/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1

Synonyms:

• 10: PN: WO2008008805 SEQID: 10 unclaimed protein
• 153: PN: US20030176421 PAGE: 54-55 claimed protein
• 16: PN: EP1498113 PAGE: 14 claimed protein
• 25: PN: WO2005095443 SEQID: 25 claimed protein
• 3: PN: WO2008052043 SEQID: 2 claimed protein
• 46: PN: US6017496 PAGE: 120 claimed protein
• 5-L-Methionine-enkephalin
• 5-Methionine enkephalin
• Adrenorphin (human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide-
• Enkephalin, methionine
• Human β-endorphin(1-5)
• L-Methionine-enkephalin
• Lupex
• Met5-enkephalin
• Metenkefalin
• Met-enkephalin
• Methionine enkephalin
• Methionyl-enkephalin
• N-[N-[N-(N-L-tirosilglicil)glicil]-L-fenilalanil]-L-metionina
• N-[N-[N-(N-L-Tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionin
• N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine
• Nsc 374896
• Opioid growth factor
• Peptid-M
• PN: US5961923 PAGE: 135 claimed protein
• Porcine β-endorphin 1-5
• Tyr-Gly-Gly-Phe-Met-OH
• β-Endorphin(1-5)
• L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
• methionine enkephalin acetate
• H-Tyr-Gly-Gly-Phe-Met-OH
• tyrosylglycylglycylphenylalanylmethionine

Met-Enkephalin

CAS: 58569-55-4

Opioid growth factor (OGF) and its receptor form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia. Exogenous OGF represses growth of human pancreatic cancer cells in culture and in nude mice. OGF therapy alone or in combination with standard chemotherapies results in enhanced inhibition of DNA synthesis and tumor growth.

Formula: C₂₇H₃₅N₅O₇S

Purity: 99.8%

Color and Shape: White

Molecular weight: 573.67

Ref: 01-4000010

H-TYR-GLY-GLY-PHE-MET-OH

CAS: 58569-55-4

Formula: C₂₇H₃₅N₅O₇S

Purity: 98%

Color and Shape: Solid

Molecular weight: 573.6611

Ref: IN-DA00E8Q0

Tyr-Gly-Gly-Phe-Met-OH

CAS: 58569-55-4

Tyr-Gly-Gly-Phe-Met-OH

Purity: ≥95%

Molecular weight: 573.66g/mol

Ref: 54-BUP11145

Met-Enkephaline

CAS: 58569-55-4

Formula: C₂₇H₃₅N₅O₇S

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 573.661

Ref: BP-BPPG049

Tyr-Gly-Gly-Phe-Met-OH

CAS: 58569-55-4

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.

Formula: C₂₇H₃₅N₅O₇S

Purity: ≥95%

Color and Shape: White Lyophilised Solid

Molecular weight: 573.66

Ref: TM-T7211

Met-enkephalin

CAS: 58569-55-4

Stability Unstable in alkaline solution
Applications Met-enkephalin is an endogenous opioid peptide that increases expression levels of δ, μ and κ-opioid receptors, inhibits growth, apoptosis and proliferation in human melanoma A375 cells. Antitumor effect via regulating dendritic cells. Regulation of the immune system, therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases.
References Wang, D., et al.: Mol. Med. Rep., 14, 5521 (2016); Feng, P., et al.: Weishengwuxue Zazhi, 35, 100 (2015); Meng, Y., et al.: Int. Immunopharmacol., 44, 61 (2017)

Formula: C₂₇H₃₅N₅O₇S

Color and Shape: Neat

Molecular weight: 573.66

Ref: TR-M225485

Methionine-Enkephalin (Human, Porcine, Bovine, Rat, Mouse)

CAS: 58569-55-4

Methionine-Enkephalin is a peptide that is derived from the amino acid methionine. It has been shown to act on ion channels and the receptor, as well as having a number of other biological effects. Methionine-Enkephalin can be used in research for pharmacology and protein interactions. This product is an antibody against methionine-enkephalin. It can be used for cell biology and immunology research, as it recognizes the peptide sequence of methionine-enkephalin. This antibody can also be used to inhibit the activity of this peptide.

Formula: C₂₇H₃₅N₅O₇S

Purity: Min. 95%

Molecular weight: 573.66 g/mol

Ref: 3D-PEK-4042-V

Methionine-Enkephalin (Human, Porcine, Bovine, Rat, Mouse)

CAS: 58569-55-4

Methionine-Enkephalin (ME) is a peptide that has been shown to bind to the opioid receptor and inhibit the production of pro-inflammatory cytokines. ME has been shown to have an inhibitory effect on human liver cells, as well as on cultured human epidermal cells. ME may also have a role in epidermal growth factor receptors, which could be related to its anti-inflammatory effects.

Formula: C₂₇H₃₅N₅O₇S•H₂O

Purity: Min. 95%

Molecular weight: 591.68 g/mol

Ref: 3D-PEK-4042