CAS 58580-55-5

Dibekacin sulfate

Description:

Dibekacin sulfate is an aminoglycoside antibiotic that is primarily used in the treatment of various bacterial infections. It is derived from the natural product of the bacterium Micromonospora purpurea. The compound exhibits broad-spectrum antibacterial activity, particularly against Gram-negative bacteria, making it effective in clinical settings. Dibekacin sulfate works by inhibiting bacterial protein synthesis, which ultimately leads to cell death. It is typically administered via injection due to its poor oral bioavailability. The sulfate form enhances its solubility and stability in solution. Common side effects associated with aminoglycosides, including nephrotoxicity and ototoxicity, may also be observed with dibekacin sulfate, necessitating careful monitoring of renal function during treatment. Additionally, resistance to aminoglycosides can develop, which is a significant concern in clinical microbiology. Overall, dibekacin sulfate is a valuable antibiotic in the therapeutic arsenal against resistant bacterial infections, although its use must be judicious to minimize adverse effects and resistance development.

Formula: C₁₈H₃₇N₅O₈·xH₂O₄S

InChI: InChI=1S/C18H37N5O8.H2O4S/c19-4-6-1-2-7(20)17(28-6)30-15-8(21)3-9(22)16(14(15)27)31-18-13(26)11(23)12(25)10(5-24)29-18;1-5(2,3)4/h6-18,24-27H,1-5,19-23H2;(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1

InChI key: InChIKey=GXKUKBCVZHBTJW-USXQJGOZSA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O.S(=O)(=O)(O)O

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-erythro-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl-(1-4))-2-deoxy-, sulfate (salt)
• Debecacin sulfate
• Debekacyl
• Dibekacin sulphate
• Icacine
• Kappabi
• Orbicin
• Panamicin
• Panimycin
• Tokocin
• Unii-A0869I992Z
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• Dibekacin sulfate
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Dibekacin sulfate JP
• Debecacin
• Einecs 261-341-0
• 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-2-deoxy-D-streptamine/sulfuric acid,(1:x)
• Dideoxykanamycin B
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-
• (2r,3r,4s,5s,6r)-4-amino-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol sulfate
• INTERMEDIATE OF ARBEKACIN
• 3',4'-Dideoxykanamycin B
• DIBEKACIN SULFATE/INTERMEDIATE OF ARBEKACIN

Dibekacin sulfate

CAS: 58580-55-5

Dibekacin sulfate, an analog of KANAMYCIN, has antitubercular as well as broad-spectrum antimicrobial properties.

Formula: C₁₈H₃₉N₅O₁₂S

Color and Shape: Solid

Molecular weight: 549.59

Ref: TM-T21036

Dibekacin sulfate

CAS: 58580-55-5

Formula: C₁₈H₃₉N₅O₁₂S

Purity: ≥ 670μg/mg (dried basis)

Color and Shape: White powder

Molecular weight: 549.59

Ref: 7W-GA4403

Dibekacin sulfate

CAS: 58580-55-5

Dibekacin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating severe gram-negative bacterial infections.

Formula: C₁₈H₃₉N₅O₁₂S

Purity: Min. 670 Μg/Mg

Color and Shape: White Powder

Molecular weight: 549.59 g/mol

Ref: 3D-AD32509