CAS 58626-38-3

m-Maleimidobenzoyl-N-hydroxysuccinimide

Description:

m-Maleimidobenzoyl-N-hydroxysuccinimide (CAS 58626-38-3) is a chemical compound commonly used in bioconjugation and protein labeling applications. It features a maleimide group, which is highly reactive towards thiol groups, allowing for the formation of stable thioether bonds with cysteine residues in proteins. The presence of the N-hydroxysuccinimide (NHS) ester enhances its reactivity with amine groups, facilitating the conjugation of biomolecules such as peptides, proteins, and antibodies. This compound is typically a solid at room temperature and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Its reactivity and specificity make it valuable in the development of targeted drug delivery systems, diagnostic assays, and the creation of bioconjugates for research purposes. Care should be taken when handling this compound, as it can be sensitive to moisture and should be stored under appropriate conditions to maintain its stability and reactivity.

Formula: C₁₅H₁₀N₂O₆

InChI: InChI=1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2

InChI key: InChIKey=LLXVXPPXELIDGQ-UHFFFAOYSA-N

SMILES: O=C1N(C2=CC(C(ON3C(=O)CCC3=O)=O)=CC=C2)C(=O)C=C1

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate
• 1-(3-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl)-1H-pyrrole-2,5-dione
• 1H-Pyrrole-2,5-dione, 1-[3-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]phenyl]-
• 3-Maleimidobenzoic acid N-hydroxysuccinimide ester
• 3-Maleimidobenzoyl N-hydroxysuccinimide
• Benzoic acid, 3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,5-dioxo-1-pyrrolidinyl ester
• N-(3-Maleimidobenzoyloxy)succinamide
• N-(m-Maleimidobenzoyloxy)succinamide
• N-(m-Maleimidobenzoyloxy)succinimide
• NSC 294786
• m-Maleimidobenzoic acid N-hydroxysuccinimide ester
• m-Maleimidobenzoyl N-hydroxysuccinimide ester
• m-Maleimidobenzoyl-N-hydroxysuccinimide

N-Succinimidyl 3-Maleimidobenzoate [Cross-linking Reagent]

CAS: 58626-38-3

Formula: C₁₅H₁₀N₂O₆

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 314.25

Ref: 3B-S0398

N-Succinimidyl 3-maleimidobenzoate, 95%

CAS: 58626-38-3

A heterobifunctional coupling reagent useful for forming enzyme immunoconjugates

Formula: C₁₅H₁₀N₂O₆

Purity: 95%

Molecular weight: 314.26

Ref: 02-J61410

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

CAS: 58626-38-3

Formula: C₁₅H₁₀N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 314.2497

Ref: IN-DA0033QL

MBS Crosslinker

CAS: 58626-38-3

MBS is a non-cleavable, water-insoluble protein crosslinker; SMPB is its extended form. SATA modifies proteins/peptides with sulfhydryl for MBS use.

Formula: C₁₅H₁₀N₂O₆

Color and Shape: Crystalline

Molecular weight: 314.25

Ref: TM-T19941

MBS Crosslinker

CAS: 58626-38-3

MBS Crosslinker

Purity: ≥95%

Molecular weight: 314.25g/mol

Ref: 54-BUP14045

3-Maleimidobenzoyl-N-hydroxysuccinimide ester

CAS: 58626-38-3

3-Maleimidobenzoyl-N-hydroxysuccinimide ester

Formula: C₁₅H₁₀N₂O₆

Purity: 98%

Color and Shape: white solid

Molecular weight: 314.25g/mol

Ref: 54-BICL202

3-N-Maleimidobenzoic acid N-succinimidyl ester

CAS: 58626-38-3

3-N-Maleimidobenzoic acid N-succinimidyl ester is a potent inhibitor of the enzyme aromatase, the enzyme responsible for the conversion of androgens to estrogens. 3-N-Maleimidobenzoic acid N-succinimidyl ester binds covalently to the active site of aromatase, thereby inhibiting its activity. This drug also has been shown to be effective in reducing the production of blood group antigens in rats. 3-N-Maleimidobenzoic acid N-succinimidyl ester binds to homologous proteins, such as albumins and hemoglobins, and inhibits their function. The drug can be used as an immunogen to produce antibodies against these proteins. Toxicity studies have been conducted with this drug in rats and mice with no observed adverse effects at doses up to 500 mg/kg.

Formula: C₁₅H₁₀N₂O₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 314.25 g/mol

Ref: 3D-FM24983

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

CAS: 58626-38-3

Formula: C₁₅H₁₀N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 314.253

Ref: 10-F492503